Bio F1B hamster: a unique animal model with reduced lipoprotein lipase activity to investigate nutrient mediated regulation of lipoprotein metabolism

Table 6 Hepatic lipid concentrations for F₁B and Golden Syrian (GS) hamsters

Hepatic lipids	Diet	Animal Strain		Statistical Analysis
(mg/g liver)		F1B	GS	Interaction	P value
Total Cholesterol	FO	6.86 ± 1.14	7.54 ± 0.43	D	P < 0.0001
	MUFA	3.36 ± 0.29	2.79 ± 0.33
	N6:N3	5.20 ± 0.89	4.48 ± 0.42
Triglycerides	FO	3.44 ± 0.57	6.13 ± 0.72	D, S	P < 0.0001
	MUFA	1.35 ± 0.35	3.12 ± 0.40
	N6:N3	1.89 ± 0.29	3.22 ± 0.24
Free Cholesterol	FO	0.65 ± 0.10	0.45 ± 0.02	___	___
	MUFA	0.52 ± 0.08	0.53 ± 0.05
	N6:N3	0.71 ± 0.13	0.66 ± 0.05
Cholesterol Esters	FO	5.75 ± 0.95	7.10 ± 0.43	D	P < 0.0001
	MUFA	3.01 ± 0.36	2.26 ± 0.41
	N6:N3	4.50 ± 0.77	3.82 ± 0.43

Hamsters were fed fish oil (FO), monounsaturated fatty acid rich (MUFA) or N6:N3 diets for 4 weeks. Lipids were analysed as described under materials and methods section. Values are means SEM, (n = 6 for F1B, n = 6 for GS). Groups were compared by two-way ANOVA, p = 0.05. D, S represents diet and strain respectively.

ISSN: 1743-7075