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Table 4 Lipid characteristics of high fat diets used to induce steatosis and steatohepatitis

From: Long term highly saturated fat diet does not induce NASH in Wistar rats

  coconut diet butter diet Lieber Zou Rivera Gauthier Fan
Rat Wistar Wistar Sprague Dawley Sprague Dawley Wistar Sprague Dawley Sprague Dawley
Fat (w/w) 45% coconut 45% butter 30.1% corn oil
17.6% olive oil
1.7% safflower oil
35.7% corn oil 15% corn oil 3.4% corn oil
14.6% lard
10% lard oil
2% cholesterol
SFA (% fat) 86.5 51.3 13 13 13 34 39
MUFA (% fat) 5.8 21 41 24 27.6 42 45
PUFA (% fat) 1.8 3 42 59 54.7 20 21
Carbohydrate (w/w) 24.7% corn starch 16.2% dextrin maltose 13.4% sucrose 50% sucrose 39% corn starch nd
Time of diet (week) 14 14 3 6 6 8 16 12
steatosis no no mild mild no yes yes yes
inflammation no no yes yes no nd nd mild
fibrosis no no yes nd no nd nd no
  1. Abbreviations: SFA, saturated fatty acid; MUFA, monounsaturated fatty acid; PUFA, polyunsaturated fatty acid; nd, not determined.