Table 4 Lipid characteristics of high fat diets used to induce steatosis and steatohepatitis
From: Long term highly saturated fat diet does not induce NASH in Wistar rats
coconut diet | butter diet | Lieber | Zou | Rivera | Gauthier | Fan | ||
|---|---|---|---|---|---|---|---|---|
Rat | Wistar | Wistar | Sprague Dawley | Sprague Dawley | Wistar | Sprague Dawley | Sprague Dawley | |
Fat (w/w) | 45% coconut | 45% butter | 30.1% corn oil 17.6% olive oil 1.7% safflower oil | 35.7% corn oil | 15% corn oil | 3.4% corn oil 14.6% lard | 10% lard oil 2% cholesterol | |
SFA (% fat) | 86.5 | 51.3 | 13 | 13 | 13 | 34 | 39 | |
MUFA (% fat) | 5.8 | 21 | 41 | 24 | 27.6 | 42 | 45 | |
PUFA (% fat) | 1.8 | 3 | 42 | 59 | 54.7 | 20 | 21 | |
Carbohydrate (w/w) | 24.7% corn starch | 16.2% dextrin maltose | 13.4% sucrose | 50% sucrose | 39% corn starch | nd | ||
Time of diet (week) | 14 | 14 | 3 | 6 | 6 | 8 | 16 | 12 |
steatosis | no | no | mild | mild | no | yes | yes | yes |
inflammation | no | no | yes | yes | no | nd | nd | mild |
fibrosis | no | no | yes | nd | no | nd | nd | no |