Activation of PPARα by PA and OA in pancreatic islets. KO and WT islets were cultured for 24 with BSA, PA or OA, then nuclear extract was prepared and PPARα activity was measured. Treatment of KO and WT islets with OA significantly increased the PPARα activity (*P < 0.05 vs BSA). The activity of PPARα significantly increased only in KO islets treated with PA (*P < 0.05) compared to BSA. Data are presented as means ± SE, N = 4 or greater for each group.