PPAR-α agonism improves whole body and muscle mitochondrial fat oxidation, but does not alter intracellular fat concentrations in burn trauma children in a randomized controlled trial

Table 3 :

	PLA		FEN
Measurement	Pre	Post	Pre	Post
LFAT (% LFAT/control)	26 ± 9	27 ± 9	24 ± 7	30 ± 9
IMCL (% IMCL/control)	27 ± 8	18 ± 7	30 ± 16	22 ± 9
Total DAG (pmol/mg)	482 ± 92	380 ± 59	341 ± 102	357 ± 75
Total Long Chain fatty acyl CoA (pmol/mg)	6.0 ± 1.1	5.0 ± 0.8	5.4 ± 0.5	6.4 ± 1.1
Total Long chain fatty Acyl carnitine (pmol/mg)	55 ± 18	62 ± 18	56 ± 13	58 ± 19
Percent of CoA/Carnitine	10 ± 6	8 ± 4	9 ± 4	10 ± 5

Basal levels of intracellular triglyceride percentages for the liver and soleus muscle are shown, and did not change with treatment in either group. Basal concentrations of total long chain species (16:0, 16:1, 18:0, 18:1 and 18:2) of DAG, fatty acyl CoA and fatty acyl carnitine also did not change with either treatment.

ISSN: 1743-7075