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Table 4 Mitochondrial oxidation and enzyme levels

From: PPAR-α agonism improves whole body and muscle mitochondrial fat oxidation, but does not alter intracellular fat concentrations in burn trauma children in a randomized controlled trial

  PLA FEN
Measurement Pre Post Pre Post
State 3 oxidation (μmol O2/mg CS/min) 0.87 ± 0.05 0.73 ± 0.07* 0.80 ± 0.10 1.17 ± 0.12*
State 4 oxidation (μmol O2/mg CS/min) 0.58 ± 0.04 0.73 ± 0.13 0.60 ± 0.06 0.60 ± 0.07
Ratio of State3/State4 1.51 ± 0.11 1.30 ± 0.31 1.40 ± 0.17 2.01 ± 0.16*
β-HAD (μmol substrate/g wet tissue/min) 5.0 ± 0.9 4.3 ± 1.4 4.0 ± 0.8 4.5 ± 0.8
  1. State 3 respiration of palmitate in (μmol 02/CS mg protein/min) improved significantly (P = 0.03) after treatment in FEN, whereas there was a significant decrease seen in PLA (P = 0.02) State 4 oxidation of palmitate in (μmol 02/CS mg protein/min) did not change with either treatment. The ratio of state 3 to state 4 palmitate oxidation improved significantly (P = 0.02) following fenofibrate treatment. The concentration of β-HAD did not change in either group with treatment. * indicates significant change from Pre to post treatment.