PPAR-α agonism improves whole body and muscle mitochondrial fat oxidation, but does not alter intracellular fat concentrations in burn trauma children in a randomized controlled trial

Table 4 Mitochondrial oxidation and enzyme levels

	PLA		FEN
Measurement	Pre	Post	Pre	Post
State 3 oxidation (μmol O₂/mg CS/min)	0.87 ± 0.05	0.73 ± 0.07*	0.80 ± 0.10	1.17 ± 0.12*
State 4 oxidation (μmol O₂/mg CS/min)	0.58 ± 0.04	0.73 ± 0.13	0.60 ± 0.06	0.60 ± 0.07
Ratio of State3/State4	1.51 ± 0.11	1.30 ± 0.31	1.40 ± 0.17	2.01 ± 0.16*
β-HAD (μmol substrate/g wet tissue/min)	5.0 ± 0.9	4.3 ± 1.4	4.0 ± 0.8	4.5 ± 0.8

State 3 respiration of palmitate in (μmol 02/CS mg protein/min) improved significantly (P = 0.03) after treatment in FEN, whereas there was a significant decrease seen in PLA (P = 0.02) State 4 oxidation of palmitate in (μmol 02/CS mg protein/min) did not change with either treatment. The ratio of state 3 to state 4 palmitate oxidation improved significantly (P = 0.02) following fenofibrate treatment. The concentration of β-HAD did not change in either group with treatment. * indicates significant change from Pre to post treatment.

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