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Table 2 Studies Which do not Support the Efficacy of HMB Supplementation in Varying Populations
| Experiment | Participants | Dosage/Duration | Biochemistry | Performance | Body Composition |
|---|---|---|---|---|---|
| Kreider et al. [64] | 40 experienced resistance trained M | 0, 3, or 6 g/day for 4 weeks | No effect markers of muscle damage | No effect on strength | No effect on LBM or FM |
| Slater et al. [65] | Experienced resistance trained M | 0, 3 g/day for 6 weeks | No effect markers of muscle damage | No effect on strength | No effect on LBM or FM |
| Paddon-Jones et al. [66], Jennifer et al. [67] | Untrained M | 0, or 3 g/day, 6 days prior to a single bout eccentric exercise | NR | No effect on soreness, ROM, or elbow flexor strength | NR |
| O'Connor and Crowe [20] | Elite M rugby players | P, 3 g/day HMB, or creatine and HMB, during season. | NR | No effect on multistage fitness test or maximal cycle test | NR |
| Jack et al. [68] | Elite collegiate football players | 0, 3 g/day for 4 weeks during football training | NR | No effect on weight lifting strength | No effect on body composition |
| Jay et al. [69] | 26 elite collegiate football players | 0, 3 g/day for 4 weeks during 10 day training camp | No effect markers of muscle damage | No effect on performance | No effect on LBM or FM |
| Kreider et al. [70] | Division 1-A College Football | 0, 3 g/day during 4 weeks of resistance training | No effect markers of muscle damage | No effect on strength or sprint performance | No effect on LBM or FM |
