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Table 2 Studies Which do not Support the Efficacy of HMB Supplementation in Varying Populations

From: Effects of beta-hydroxy-beta-methylbutyrate (HMB) on exercise performance and body composition across varying levels of age, sex, and training experience: A review

Experiment Participants Dosage/Duration Biochemistry Performance Body Composition
Kreider et al. [64] 40 experienced resistance trained M 0, 3, or 6 g/day for 4 weeks No effect markers of muscle damage No effect on strength No effect on LBM or FM
Slater et al. [65] Experienced resistance trained M 0, 3 g/day for 6 weeks No effect markers of muscle damage No effect on strength No effect on LBM or FM
Paddon-Jones et al. [66], Jennifer et al. [67] Untrained M 0, or 3 g/day, 6 days prior to a single bout eccentric exercise NR No effect on soreness, ROM, or elbow flexor strength NR
O'Connor and Crowe [20] Elite M rugby players P, 3 g/day HMB, or creatine and HMB, during season. NR No effect on multistage fitness test or maximal cycle test NR
Jack et al. [68] Elite collegiate football players 0, 3 g/day for 4 weeks during football training NR No effect on weight lifting strength No effect on body composition
Jay et al. [69] 26 elite collegiate football players 0, 3 g/day for 4 weeks during 10 day training camp No effect markers of muscle damage No effect on performance No effect on LBM or FM
Kreider et al. [70] Division 1-A College Football 0, 3 g/day during 4 weeks of resistance training No effect markers of muscle damage No effect on strength or sprint performance No effect on LBM or FM
  1. M = Male; F = Female; LBM = Lean body mass; P = Placebo; FM = Fat mass; NR = Not reported.