Skip to main content

Table 2 The levels of albumin, total protein and total bilirubin after the treatment of rats with antituberculosis drugs and silymarin.

From: Silymarin protects liver against toxic effects of anti-tuberculosis drugs in experimental animals

Groups Albumin (gr/dl) Total Protein (gr/dl) Total Bilirubin (mg/dl)
I (control) 4.20 ± 0.40 7.27 ± 0.32 0.095 ± 0.022
II (silymarin control) 4.42 ± 0.40 7.49 ± 0.34 0.099 ± 0.021
III (INH+RIF) 3.44 ± 0.32* 5.80 ± 0.59* 0.194 ± 0.052*
IV (INH+RIF+PZA) 3.35 ± 0.17* 5.70 ± 0.48* 0.199 ± 0.049*
V (INH+RIF+Silymarin) 4.02 ± 0.28** 6.84 ± 0.41** 0.118 ± 0.036**
VI (INH+RIF+PZA+Silymarin) 3.95 ± 0.47*** 6.85 ± 0.59** 0.137 ± 0.026**
  1. Values represent mean ± SD. Constant doses of INH (50 mg/kg), RIF (100 mg/kg), PZA (350 mg/kg) and silymarin (200 mg/kg) were used. *P < 0.001 as compared to the controls (Groups I and II). ** P < 0.01 as compared to the controls (Groups I and II) and hepatotoxicity groups (Groups II and IV). *** P < 0.05 significant difference from the hepatotoxicity groups but not the control.