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Table 2 The levels of albumin, total protein and total bilirubin after the treatment of rats with antituberculosis drugs and silymarin.

From: Silymarin protects liver against toxic effects of anti-tuberculosis drugs in experimental animals

Groups

Albumin (gr/dl)

Total Protein (gr/dl)

Total Bilirubin (mg/dl)

I (control)

4.20 ± 0.40

7.27 ± 0.32

0.095 ± 0.022

II (silymarin control)

4.42 ± 0.40

7.49 ± 0.34

0.099 ± 0.021

III (INH+RIF)

3.44 ± 0.32*

5.80 ± 0.59*

0.194 ± 0.052*

IV (INH+RIF+PZA)

3.35 ± 0.17*

5.70 ± 0.48*

0.199 ± 0.049*

V (INH+RIF+Silymarin)

4.02 ± 0.28**

6.84 ± 0.41**

0.118 ± 0.036**

VI (INH+RIF+PZA+Silymarin)

3.95 ± 0.47***

6.85 ± 0.59**

0.137 ± 0.026**

  1. Values represent mean ± SD. Constant doses of INH (50 mg/kg), RIF (100 mg/kg), PZA (350 mg/kg) and silymarin (200 mg/kg) were used. *P < 0.001 as compared to the controls (Groups I and II). ** P < 0.01 as compared to the controls (Groups I and II) and hepatotoxicity groups (Groups II and IV). *** P < 0.05 significant difference from the hepatotoxicity groups but not the control.
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Nutrition & Metabolism

ISSN: 1743-7075

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