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Table 3 Histological evaluation of liver tissues by light microscopy.

From: Silymarin protects liver against toxic effects of anti-tuberculosis drugs in experimental animals

  Group I Group II Group III Group IV Group V Group VI
Degeneration 0/10 0/10 10/10 10/10 6/10 6/10
Steatosis 0/10 0/10 7/10 7/10 3/10 2/10
Necrosis 0/10 0/10 7/10 8/10 2/10 2/10
Triaditis 0/10 0/10 8/10 8/10 0/10 0/10
Fibrosis 0/10 0/10 0/10 0/10 0/10 0/10
Regeneration 0/10 0/10 0/10 0/10 0/10 0/10
  1. Constant doses of INH (50 mg/kg), RIF (100 mg/kg), PZA (350 mg/kg) and silymarin (200 mg/kg) were used. Group I: Control, Group II: Silymarin control, Group III: INH+RIF, Group IV: INH+RIF+PZA, Group V: INH+RIF+Silymarin, and Group VI: INH+RIF+PZA+Silymarin.