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Table 3 Histological evaluation of liver tissues by light microscopy.

From: Silymarin protects liver against toxic effects of anti-tuberculosis drugs in experimental animals

 

Group I

Group II

Group III

Group IV

Group V

Group VI

Degeneration

0/10

0/10

10/10

10/10

6/10

6/10

Steatosis

0/10

0/10

7/10

7/10

3/10

2/10

Necrosis

0/10

0/10

7/10

8/10

2/10

2/10

Triaditis

0/10

0/10

8/10

8/10

0/10

0/10

Fibrosis

0/10

0/10

0/10

0/10

0/10

0/10

Regeneration

0/10

0/10

0/10

0/10

0/10

0/10

  1. Constant doses of INH (50 mg/kg), RIF (100 mg/kg), PZA (350 mg/kg) and silymarin (200 mg/kg) were used. Group I: Control, Group II: Silymarin control, Group III: INH+RIF, Group IV: INH+RIF+PZA, Group V: INH+RIF+Silymarin, and Group VI: INH+RIF+PZA+Silymarin.