Weight gain of pups and breeders. A. Body weights of pups. Symbols and error bars represent means ± SEM for each dietary group at each time point. N = 23–24 rats/group up to 35 days, N = 15–16 rats/group from 35–100 days, and from 100–200 days N = 8 rats/group. By ANOVA, diet was a significant determinant (p < 0.005) of body weight as early as 35 days, which significance continued until the end of the study. At 35 days and 200 days means not sharing a common superscript are significantly (p < 0.05) different by Fisher's pairwise comparisons. The main effect of isoflavones was statistically significant at each time point (p = 0.047 and p = 0.001 at 35 days and 200 days, respectively) while the main effect of Se was not. B. Body weights of breeders. N = 3–4 for each dietary group at each time point. Symbols and error bars represent means ± SEM for each dietary group at each time point. There were no statistically significant effects of diet on body weight at any time point. Abbreviations: Adequate (0.33–0.45 mg/kg diet) Se, Adq. Se; High (3.33–3.45 mg/kg) Se, High Se; Low (10 mg/kg) isoflavones, Low IF; High (600 mg/kg) isoflavones, High IF.