Figure 2

Physiogenomic representation of the most significant genetic associations found in the low fat diet group. Individual patient genotypes (circles) of each SNP are overlaid on the distribution of Δ%BF (thin line). Each circle represents a patient, with the horizontal axis specifying the Δ%BF, and the vertical axis the carrier status for the minor allele: bottom, non-carriers; middle, single-carriers; top, double-carriers. A LOESS fit of the allele frequency (thick line) as a function of Δ%BF is shown. The ordinate is labeled for the marker frequency (thick line) of the SNP denoted at the top of each panel. The ordinate scale is the same in all three panels. The ordinate scales for the genotypes (circles) and Δ%BF distribution (thin line) are not shown. The abscissa is labeled for Δ%BF in each panel. The abscissa scale is the same in all three panels and applies identically to marker frequency, genotypes, and Δ%BF distribution.