Table 2 Genes and SNPs analyzed for associations with percent body fat change profiles for LF and LC groups.
From: Physiogenomic comparison of human fat loss in response to diets restrictive of carbohydrate or fat
| Area | Pathway | Gene | Symbol | SNP | Type |
|---|---|---|---|---|---|
| Food Intake | Neural | galanin | GAL | rs694066 | intron 1 |
| leptin receptor | LEPR | rs7602 | intron 1 (3' UTR on another gene) | ||
| rs1171276 | intron 1 (untranslated) | ||||
| rs8179183 | exon 12, N656K | ||||
| melanocortin 3 receptor | MC3R | rs6024725 | ~10 kb upstream | ||
| neuropeptide Y | NPY | rs1468271 | intron 1 | ||
| neuropeptide Y receptor Y5 | NPY5R | rs11100494 | intron 3 | ||
| rs6837793 | ~9 kb upstream | ||||
| Neural/Gut | histamine N-methyltransferase | HNMT | rs1801105 | exon 4, I105T | |
| rs12691940 | intron 2 | ||||
| Gut | apolipoprotein A-IV | APOA4 | rs675 | T367S, exon 3 | |
| rs5092 | exon 2, T29T | ||||
| ghrelin precursor | GHRL | rs26312 | ~1 kb upstream | ||
| lipase, gastric | LIPF | rs814628 | exon 4, A161T | ||
| peptide YY | PYY | rs1058046 | exon 2, R72T | ||
| rs231460 | ~1.8 kb upstream | ||||
| Energy Homeostasis | Metabolic Enzyme | glycogen synthase kinase 3 beta | GSK3B | rs4688046 | intron 3 |
| rs334555 | intron 1 | ||||
| rs10934502 | intron 2 | ||||
| glycogen synthase 1 (muscle) | GYS1 | rs2287754 | 5' UTR | ||
| glycogen synthase 2 (liver) | GYS2 | rs1478290 | upstream, ~3.5 Kb | ||
| rs2306179 | intron 5 | ||||
| rs10505873 | intron 3 | ||||
| phosphofructokinase, liver | PFKL | rs2838549 | intron 8 | ||
| phosphofructokinase, muscle | PFKM | rs2269935 | ~700 bp upstream | ||
| pyruvate kinase, liver and RBC | PKLR | rs3762272 | intron 2 | ||
| pyruvate kinase, muscle | PKM2 | rs2856929 | intron 7 (MT) | ||
| Nuclear Signaling | retinoic acid receptor, alpha | RARA | rs4890109 | intron 3 | |
| rs9904270 | ~7.5 kb upstream | ||||
| retinoic acid receptor, beta | RARB | rs2033447 | intron 2 (MT) | ||
| rs1290443 | intron 3 (MT) | ||||
| rs322695 | ~100 kb upstream | ||||
| retinoic acid receptor, gamma | RARG | rs10082776 | intron 2 (untranslated) | ||
| retinoid X receptor, alpha | RXRA | rs4917348 | ~100 kbp upstream | ||
| rs3750546 | ~100 kb upstream | ||||
| rs3118536 | intron 3 | ||||
| retinoid X receptor, gamma | RXRG | rs157864 | intron 4 | ||
| Adipocyte Regulation | Adipokine-related | adiponectin receptor 2 | ADIPOR2 | rs2058112 | intron 1 (untranslated?) |
| rs7975375 | intron 1 (untranslated?) | ||||
| angiotensin II receptor, type 1 | AGTR1 | rs12695902 | intron 3 | ||
| rs931490 | intron 2 (untranslated?), (MT) | ||||
| angiotensin II receptor, type 2 | AGTR2 | rs5950584 | ~4.5 kb upstream | ||
| resistin | RETN | rs3219177 | intron 1 | ||
| Lipid Metabolic | apolipoprotein E | APOE | rs7412 | exon 3, C176R, *2–>*3 | |
| rs429358 | exon 3, R130C, *4–>*3 | ||||
| rs405509 | ~200 bp upstream | ||||
| rs439401 | ~1.5 kbp downstream | ||||
| rs446037 | ~1.5 kbp upstream | ||||
| cholesteryl ester transfer protein, plasma | CETP | rs5883 | exon 9, F287F | ||
| rs1532624 | intron 7 | ||||
| rs3764261 | ~2.6 kb upstream | ||||
| rs5880 | nonsynonymous, P390A |