Table 2 Genes and SNPs analyzed for associations with percent body fat change profiles for LF and LC groups.
From: Physiogenomic comparison of human fat loss in response to diets restrictive of carbohydrate or fat
Area | Pathway | Gene | Symbol | SNP | Type |
|---|---|---|---|---|---|
Food Intake | Neural | galanin | GAL | rs694066 | intron 1 |
| Â | Â | leptin receptor | LEPR | rs7602 | intron 1 (3' UTR on another gene) |
| Â | Â | Â | Â | rs1171276 | intron 1 (untranslated) |
| Â | Â | Â | Â | rs8179183 | exon 12, N656K |
| Â | Â | melanocortin 3 receptor | MC3R | rs6024725 | ~10 kb upstream |
| Â | Â | neuropeptide Y | NPY | rs1468271 | intron 1 |
| Â | Â | neuropeptide Y receptor Y5 | NPY5R | rs11100494 | intron 3 |
| Â | Â | Â | Â | rs6837793 | ~9 kb upstream |
| Â | Neural/Gut | histamine N-methyltransferase | HNMT | rs1801105 | exon 4, I105T |
| Â | Â | Â | Â | rs12691940 | intron 2 |
| Â | Gut | apolipoprotein A-IV | APOA4 | rs675 | T367S, exon 3 |
| Â | Â | Â | Â | rs5092 | exon 2, T29T |
| Â | Â | ghrelin precursor | GHRL | rs26312 | ~1 kb upstream |
| Â | Â | lipase, gastric | LIPF | rs814628 | exon 4, A161T |
| Â | Â | peptide YY | PYY | rs1058046 | exon 2, R72T |
| Â | Â | Â | Â | rs231460 | ~1.8 kb upstream |
Energy Homeostasis | Metabolic Enzyme | glycogen synthase kinase 3 beta | GSK3B | rs4688046 | intron 3 |
| Â | Â | Â | Â | rs334555 | intron 1 |
| Â | Â | Â | Â | rs10934502 | intron 2 |
| Â | Â | glycogen synthase 1 (muscle) | GYS1 | rs2287754 | 5' UTR |
| Â | Â | glycogen synthase 2 (liver) | GYS2 | rs1478290 | upstream, ~3.5 Kb |
| Â | Â | Â | Â | rs2306179 | intron 5 |
| Â | Â | Â | Â | rs10505873 | intron 3 |
| Â | Â | phosphofructokinase, liver | PFKL | rs2838549 | intron 8 |
| Â | Â | phosphofructokinase, muscle | PFKM | rs2269935 | ~700 bp upstream |
| Â | Â | pyruvate kinase, liver and RBC | PKLR | rs3762272 | intron 2 |
| Â | Â | pyruvate kinase, muscle | PKM2 | rs2856929 | intron 7 (MT) |
| Â | Nuclear Signaling | retinoic acid receptor, alpha | RARA | rs4890109 | intron 3 |
| Â | Â | Â | Â | rs9904270 | ~7.5 kb upstream |
| Â | Â | retinoic acid receptor, beta | RARB | rs2033447 | intron 2 (MT) |
| Â | Â | Â | Â | rs1290443 | intron 3 (MT) |
| Â | Â | Â | Â | rs322695 | ~100 kb upstream |
| Â | Â | retinoic acid receptor, gamma | RARG | rs10082776 | intron 2 (untranslated) |
| Â | Â | retinoid X receptor, alpha | RXRA | rs4917348 | ~100 kbp upstream |
| Â | Â | Â | Â | rs3750546 | ~100 kb upstream |
| Â | Â | Â | Â | rs3118536 | intron 3 |
| Â | Â | retinoid X receptor, gamma | RXRG | rs157864 | intron 4 |
Adipocyte Regulation | Adipokine-related | adiponectin receptor 2 | ADIPOR2 | rs2058112 | intron 1 (untranslated?) |
| Â | Â | Â | Â | rs7975375 | intron 1 (untranslated?) |
| Â | Â | angiotensin II receptor, type 1 | AGTR1 | rs12695902 | intron 3 |
| Â | Â | Â | Â | rs931490 | intron 2 (untranslated?), (MT) |
| Â | Â | angiotensin II receptor, type 2 | AGTR2 | rs5950584 | ~4.5 kb upstream |
| Â | Â | resistin | RETN | rs3219177 | intron 1 |
|  | Lipid Metabolic | apolipoprotein E | APOE | rs7412 | exon 3, C176R, *2–>*3 |
|  |  |  |  | rs429358 | exon 3, R130C, *4–>*3 |
| Â | Â | Â | Â | rs405509 | ~200 bp upstream |
| Â | Â | Â | Â | rs439401 | ~1.5 kbp downstream |
| Â | Â | Â | Â | rs446037 | ~1.5 kbp upstream |
| Â | Â | cholesteryl ester transfer protein, plasma | CETP | rs5883 | exon 9, F287F |
| Â | Â | Â | Â | rs1532624 | intron 7 |
| Â | Â | Â | Â | rs3764261 | ~2.6 kb upstream |
| Â | Â | Â | Â | rs5880 | nonsynonymous, P390A |