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Table 1 Changes in diabetes medication of 19 overweight participants with type 2 diabetes who underwent a 16-week diet intervention trial. Patients were provided with VLCKD counseling with an initial goal of <20 g carbohydrate/day. Medication was reduced at diet initiation. Data from Yancy, et al. [62].

From: Dietary carbohydrate restriction in type 2 diabetes mellitus and metabolic syndrome: time for a critical appraisal

Patient number Daily Dose – Week 0 Daily Dose – Week 16
Medications discontinued (n = 7 of 19 originally on medication)
5 glipizide 10 mg none
  metformin 1000 mg  
6 metformin 1500 mg none
7   none
9 metformin 1000 mg none
15 metformin 1000 mg none
22 metformin 1000 mg none
24 metformin 1000 mg none
Medications reduced (n = 10 of 19)
3 70/30 insulin 50 units metformin 1000 mg
  metformin 1000 mg  
11 metformin 2000 mg metformin 2000 mg
  glyburide 20 mg  
16 metformin 2000 mg metformin 2000 mg
  pioglitazone 45 mg  
  glypizide 20 mg  
21 metformin 1500 mg metformin 1000 mg
  pioglitazone 30 mg  
8 NPH 145 units NPH 25 units
  metformin 1000 mg metformin 1000 mg
13 70/30 insulin 70 units 70/30 insulin 35 units
  metformin 2550 mg metformin 2550 mg
23 70/30 insulin 110 units 70/30 insulin 80 units
  pioglitazone 45 mg pioglitazone 45 mg
   metformin 1000 mg
25 NPH 70 units, r 30 units NPH 8 units
  metformin 2000 mg metformin 2000 mg
  pioglitazone 45 mg pioglitazone 45 mg
27 70/30 insulin 86 units 70/30 insulin 18 units
  metformin 2000 mg metformin 2000 mg
28 NPH insulin 90 units NPH insulin 30 units
  lispro insulin 90 units glypizide 20 mg
  glypizide 20 mg