Effects of alpha-linolenic acid vs. docosahexaenoic acid supply on the distribution of fatty acids among the rat cardiac subcellular membranes after a short- or long-term dietary exposure

Brochot, Amandine; Guinot, Marine; Auchere, Daniel; Macaire, Jean-Paul; Weill, Pierre; Grynberg, Alain; Rousseau-Ralliard, Delphine

doi:10.1186/1743-7075-6-14

Table 2 Plasma fatty acid profiles (% of total fatty acids) from rats fed experimental diets for 2 or 6 months.

From: Effects of alpha-linolenic acid vs. docosahexaenoic acid supply on the distribution of fatty acids among the rat cardiac subcellular membranes after a short- or long-term dietary exposure

Duration (months)	2	2	2	6	6	6
Dietary groups	CTL	DHA	ALA	CTL	DHA	ALA
Fatty acids:							CI
14:0	0.6 ± 0.6	0.2 ± 0.1	0.2 ± 0.0	1.0 ± 0.2	1.0 ± 0.2***	0.8 ± 0.1	-
16:0	14.6 ± 1.3^b	17.3 ± 1.4^a	17.6 ± 0.8^a	20.0 ± 0.8^b ***	24.2 ± 0.8^a ***	22.3 ± 0.8^a ***	-
16:1 n-9	0.2 ± 0.1	0.2 ± 0.0	0.2 ± 0.0	0.3 ± 0.0	0.3 ± 0.1***	0.4 ± 0.0	-
16:1 n-7	1.7 ± 0.1	2.0 ± 0.6	2.2 ± 0.4	2.4 ± 0.8	2.7 ± 0.7	2.4 ± 0.8	-
18:0	12.1 ± 1.0^b	12.2 ± 0.5^b	13.7 ± 1.0^a	12.3 ± 0.9^b	13.2 ± 1.0^b	14.5 ± 0.8^a	-
18:1 n-9	15.4 ± 0.9	16.8 ± 0.9	15.5 ± 1.0	15.4 ± 1.2*	14.9 ± 2.1*	13.9 ± 0.5*	-
18:1 n-7	2.1 ± 0.2	1.8 ± 0.1	1.9 ± 0.2	2.2 ± 0.4^a	1.7 ± 0.2^b	1.6 ± 0.1^b	-
18:2 n-6	27.3 ± 1.4^a	19.3 ± 1.4^b	20.3 ± 1.0^b	25.5 ± 1.3^a *	19.0 ± 0.9^b	18.7 ± 0.9^b	-
18:3 n-6	0.4 ± 0.1^a	0.3 ± 0.1^a	<0.1^b	0.5 ± 0.1^a	<0.1^c	0.2 ± 0.1^b	-
18:3 n-3	0.3 ± 0.0^b	0.7 ± 0.1^b	8.4 ± 0.9^a	0.3 ± 0.0^b	0.7 ± 0.1^b	8.1 ± 0.4^a	-
20:3 n-6	0.5 ± 0.1^b	0.4 ± 0.1^b	0.7 ± 0.2^a	0.5 ± 0.1^a	0.4 ± 0.1^b	0.6 ± 0.1^a	-
20:4 n-6	21.3 ± 0.6^a	7.4 ± 0.9^b	7.5 ± 0.6^b	16.7 ± 1.7^a ***	6.7 ± 1.0^b	6.7 ± 0.5^b	-
20:5 n-3	<0.1^b	5.7 ± 0.8^a	5.6 ± 0.8^a	<0.1^c	3.4 ± 0.4^b ***	4.8 ± 0.3^a ***	$
22:4 n-6	0.5 ± 0.1^a	<0.1^b	<0.1^b	0.4 ± 0.1^a	<0.1^b	<0.1^b	-
22:5 n-6	0.5 ± 0.1^a	0.5 ± 0.0^a	<0.1^b	0.4 ± 0.1^a	0.1 ± 0.01^a	<0.1^b	-
22:5 n-3	0.1 ± 0.0^c	1.0 ± 0.2^b	1.8 ± 0.2^a	<0.1^c	0.6 ± 0.1^b ***	1.4 ± 0.2^a ***	$
22:6 n-3	0.8 ± 0.1^c	12.6 ± 0.7^a	2.8 ± 0.4^b	0.6 ± 0.1^c	9.3 ± 0.4^a ***	2.2 ± 0.3^b	$
SFA	27.8 ± 1.7^b	30.3 ± 1.4^a	32.0 ± 1.0^a	33.8 ± 0.5^b ***	38.9 ± 1.4^a ***	38.1 ± 0.6^a ***	-
MUFA	19.9 ± 1.1	21.2 ± 1.6	20.2 ± 1.5	20.7 ± 2.1	19.9 ± 2.2	18.6 ± 0.8	-
PUFA	52.2 ± 0.7^a	48.5 ± 2.6^b	47.8 ± 1.1^b	45.5 ± 2.1^a ***	41.2 ± 1.8^b ***	43.3 ± 0.6^b ***	-
n-6 PUFA	50.8 ± 0.8^a	28.4 ± 2.1^b	28.8 ± 1.6^b	44.3 ± 2.0^a ***	27.2 ± 1.6^b	26.4 ± 0.9^b	$
n-3 PUFA	1.3 ± 0.1^b	20.1 ± 1.5^a	18.9 ± 1.1^a	1.1 ± 0.1^b	14.0 ± 0.6^a ***	16.8 ± 0.7^a ***	$
n-6/n-3 ratio	37.9 ± 2.8^a	1.4 ± 0.2^b	1.5 ± 0.2^b	40.1 ± 1.2^a *	1.9 ± 0.1^b *	1.6 ± 0.1^b *	-
P/S ratio	1.9 ± 0.1^a	1.6 ± 0.2^b	1.5 ± 0.1^b	1.3 ± 0.1^a ***	1.1 ± 0.1^b ***	1.1 ± 0.0^b ***	-
[plasma FA] (μg/mL)	803 ± 6.8^a	427 ± 49.7^b	590 ± 35.2^b	858 ± 14.4^a *	441 ± 67.2^b	519 ± 32.4^b	$

SFA. MUFA. and PUFA. saturated. monounsaturated. and polyunsaturated FA; CTL. n-3 PUFA free diet; DHA. docosahexaenoic acid-rich diet; ALA. alpha linolenic acid-rich diet.
Data are means ± SEM. n = 4. Dietary effect (CTL versus DHA versus ALA) was compared in rats from the same dietary treatment duration and values with different letters are statistically different. a>b>c. p < 0.01. Time effect (2 months versus 6 months) was compared between rats from the same dietary group. with * = p < 0.05; ** = p < 0.01. *** = p < 0.001). Symbol $ denoted significant cross-interaction. p < 0.05.

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ISSN: 1743-7075

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