Postprandial changes in plasma triglycerides, non-esterified fatty acids, ASP and leptin. Blood samples were collected after a 12 hour fast and then subsequently at 2, 4, 6, and 8 hours after ingestion of a fatty meal in 4 groups: African American non-obese women (AA-L, filled squares, solid line, n = 10). African American obese women (AA-O, filled circles, solid line, n = 7), Caucasian American non-obese women (CA-L, open squares, dotted line, n = 10), and Caucasian American obese women (CA-O, open circles, dotted line, n = 8) for triglyceride (A), non-esterified fatty acids (B), ASP (C) and leptin (D) expressed as averages ± SEM. Non-obese and obese groups were matched for BMI between races. Significant differences were as follows: panel A: TG time course p < 0.01 for AAL vs AAO and CAO, and TG area-under-the curve (AUC)(insert) ** P < 0.01 *** p < 0.001; Panel B: NEFA time course: * p < 0.01 for 6 hours vs. zero, 2 hours and four hours; Panel C: ASP time course and ASP AUC (insert). There was a significant race affect with CA-L and CA-O women having significantly greater ASP AUC than the AA counterparts, * p < 0.05, ** p < 0.01 and *** 0.001 vs AA-L and # p < 0.05 vs. CA-O; Panel D: Leptin time course was significantly differences between non-obese and obese subjects within each race (AA: p < 0.001, CA: p < 0.001), further, AA-O were significantly lower than CA-O at all time points, p < 0.001.