Figure 4

Mean change in ADAS-Cog scores from Baseline in per protocol and dosage compliant populations without LOCF and stratified by APOE4 carriage status. Y axis is change from Baseline. X axis is time in days. Solid red circles and lines represent per protocol subjects taking AC-1202. Solid blue squares and lines represent per protocol subjects taking Placebo. Open red circles and dashed lines represent dosage compliant subjects taking AC-1202. Open blue squares and dashed lines represent dosage compliant subjects taking Placebo. Error bars represent standard error of the mean. Asterisks (*) indicate a significant (p-value < 0.05) difference in mean change from Baseline between AC-1202 and Placebo. A) Per protocol and dosage compliant subjects administered AC-1202 regardless of genotype, both cohorts demonstrate a significant difference from Placebo at Day 45. B) Per protocol and dosage compliant subjects lacking the APOE4 allele (APOE4(-)) and administered AC-1202 demonstrate a significant difference from Placebo at both Days 45 and 90. C) Per protocol and dosage compliant subjects carrying the APOE4 allele (APOE4(+)) do not differ at any time point. For number of subjects, confidence intervals, and p-values, see Tables 6 and 7.