Plot of change in ADAS-Cog and total dose administered for each of the per protocol participants. Y axis is change in ADAS-Cog score from Baseline. X axis is total dose in grams. Each subject is represented by three symbols. A red x represents the change from Baseline score at Day 45. A green square represents the change from Baseline at Day 90. A blue diamond represents the change from Baseline at Day 104. APOE4(-) subjects who received more than 4000 grams generally improved in ADAS-Cog score.