Figure 3
From: Early responses of insulin signaling to high-carbohydrate and high-fat overfeeding
PI 3-kinase activity and subunit expression. IRS-1-associated PI 3-kinase activity (A), IRS-1-associated p110 protein expression (B), and Total p85α protein expression (C) in skeletal muscle following Eucaloric feeding (EC), high-carbohydrate overfeeding (HC), and high-fat overfeeding (HF). HC overfeeding increased IRS-1 associated PI 3-kinase activity and IRS-1 associated p110 expression compared to EC feeding. HF overfeeding increased total p85α expression compared to EC feeding.