Plasma homocysteine in adolescents depends on the interaction between methylenetetrahydrofolate reductase genotype, lipids and folate: a seroepidemiological study

Table 3 Prevalence of cardiovascular risk factors and lipid profile

	Total (%)	Gender*		Age*			MTHFR C677T genotype*
		Male	Female	13	14	>14	CC	CT	TT
Overweight	30.3	35.9	25.6	ns			ns
Hypertension	8.5	ns		ns			ns
Glucose (≥ 100 mg/dl)	15.3	22	9.6	ns			ns
Total cholesterol (≥ 200 mg/dl)	7.0	2.8	10.5	ns			ns
HDL cholesterol (≤ 35 mg/dl)	13.8	20.1	8.3	ns			ns
LDL cholesterol (≥ 130 mg/dl)	6.4	ns		ns			ns
Total cholesterol/cHDL (>5en ♂/4.5 en ♀)	9.1	ns		ns			ns
cLDL/cHDL (>3.5 ♂/3 ♀)	8.5	ns		ns			ns
Smoking	7.6	ns		3.2	14.5	19.1	ns
Alcohol	9.8	ns		1.9	12.5	12.8	ns
Sedentariness	17.7	9	25.1	ns			ns
Folate (≤ 5.3 nmol/l)	23.8	ns		ns			18.8	20.4	46.7**
Vitamin B₁₂ (≤ 336 pmol/l)	24.6	30.3	10	ns			ns

*Statistically significant p < 0.05. ns: non-significant; ** differences in folate deficit were statistically significant (p < 0.001) only for homozygotic TT mutation. CT heterozygotic mutation does not show an statistically significant difference (p = 0.758)
HDL: High Density Lipoproteins
LDL: Low Density Lipoproteins
MTHFR: methylenetetrahydrofolate reductase
C: Cytosine; T:Thymine

ISSN: 1743-7075