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Table 3 Prevalence of cardiovascular risk factors and lipid profile

From: Plasma homocysteine in adolescents depends on the interaction between methylenetetrahydrofolate reductase genotype, lipids and folate: a seroepidemiological study

  Total (%) Gender* Age* MTHFR C677T genotype*
   Male Female 13 14 >14 CC CT TT
Overweight 30.3 35.9 25.6 ns ns
Hypertension 8.5 ns ns ns
Glucose (≥ 100 mg/dl) 15.3 22 9.6 ns ns
Total cholesterol (≥ 200 mg/dl) 7.0 2.8 10.5 ns ns
HDL cholesterol (≤ 35 mg/dl) 13.8 20.1 8.3 ns ns
LDL cholesterol (≥ 130 mg/dl) 6.4 ns ns ns
Total cholesterol/cHDL
(>5en ♂/4.5 en ♀)
9.1 ns ns ns
cLDL/cHDL
(>3.5 ♂/3 ♀)
8.5 ns ns ns
Smoking 7.6 ns 3.2 14.5 19.1 ns
Alcohol 9.8 ns 1.9 12.5 12.8 ns
Sedentariness 17.7 9 25.1 ns ns
Folate (≤ 5.3 nmol/l) 23.8 ns ns 18.8 20.4 46.7**
Vitamin B12
(≤ 336 pmol/l)
24.6 30.3 10 ns ns
  1. *Statistically significant p < 0.05. ns: non-significant; ** differences in folate deficit were statistically significant (p < 0.001) only for homozygotic TT mutation. CT heterozygotic mutation does not show an statistically significant difference (p = 0.758)
  2. HDL: High Density Lipoproteins
  3. LDL: Low Density Lipoproteins
  4. MTHFR: methylenetetrahydrofolate reductase
  5. C: Cytosine; T:Thymine