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Table 2 Effect of acute alcohol intoxication on liver IGFBP mRNA content in young and mature adult male F344 rats

From: Alcohol-induced decrease in muscle protein synthesis associated with increased binding of mTOR and raptor: Comparable effects in young and mature rats

 

Young

Mature – Low Dose EtOH*

Mature – High Dose EtOH

 

Control

Alcohol

Control

Alcohol

Control

Alcohol

IGFBP-1, AU/L32

1.00 ± 0.08a

1.78 ± 0.22b

0.91 ± 0.17a

1.21 ± 0.19a

0.94 ± 0.09a

2.68 ± 0.26c

IGFBP-2, AU/L32

1.00 ± 0.08a

0.64 ± 0.05b

0.45 ± 0.08b

0.52 ± 0.05b

0.47 ± 0.06b

0.49 ± 0.09b

IGFBP-3, AU/L32

1.00 ± 0.11

1.05 ± 0.15

0.87 ± 0.11

0.79 ± 0.09

0.84 ± 0.08

0.78 ± 0.14

IGFBP-4, AU/L32

1.00 ± 0.07

1.18 ± 0.12

0.90 ± 0.08

0.97 ± 0.07

0.89 ± 0.11

0.95 ± 0.09

ALS, AU/L32

1.00 ± 0.09a

0.68 ± 0.07b

1.11 ± 0.11a

1.01 ± 0.11a

1.08 ± 0.09a

0.61 ± 0.07b

  1. Values are means ± SEM where the sample size was 10, 10, 6, 7, 9, and 9 for the six groups, respectively. *Mature rats were administered either "low" dose alcohol (75 mmol/kg) or "high" dose alcohol (90 mmol/kg); young rats were injected with 75 mmol/kg. Abundance of IGFBP-5 was below the detection limit for liver in all animals and data are not reported. Values with different letters for a particular hormone are significantly different from each other, P < 0.05. Values with the same letter are not significantly different.