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Table 2 Effect of acute alcohol intoxication on liver IGFBP mRNA content in young and mature adult male F344 rats

From: Alcohol-induced decrease in muscle protein synthesis associated with increased binding of mTOR and raptor: Comparable effects in young and mature rats

  Young Mature – Low Dose EtOH* Mature – High Dose EtOH
  Control Alcohol Control Alcohol Control Alcohol
IGFBP-1, AU/L32 1.00 ± 0.08a 1.78 ± 0.22b 0.91 ± 0.17a 1.21 ± 0.19a 0.94 ± 0.09a 2.68 ± 0.26c
IGFBP-2, AU/L32 1.00 ± 0.08a 0.64 ± 0.05b 0.45 ± 0.08b 0.52 ± 0.05b 0.47 ± 0.06b 0.49 ± 0.09b
IGFBP-3, AU/L32 1.00 ± 0.11 1.05 ± 0.15 0.87 ± 0.11 0.79 ± 0.09 0.84 ± 0.08 0.78 ± 0.14
IGFBP-4, AU/L32 1.00 ± 0.07 1.18 ± 0.12 0.90 ± 0.08 0.97 ± 0.07 0.89 ± 0.11 0.95 ± 0.09
ALS, AU/L32 1.00 ± 0.09a 0.68 ± 0.07b 1.11 ± 0.11a 1.01 ± 0.11a 1.08 ± 0.09a 0.61 ± 0.07b
  1. Values are means ± SEM where the sample size was 10, 10, 6, 7, 9, and 9 for the six groups, respectively. *Mature rats were administered either "low" dose alcohol (75 mmol/kg) or "high" dose alcohol (90 mmol/kg); young rats were injected with 75 mmol/kg. Abundance of IGFBP-5 was below the detection limit for liver in all animals and data are not reported. Values with different letters for a particular hormone are significantly different from each other, P < 0.05. Values with the same letter are not significantly different.