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Table 3 Effect of acute alcohol intoxication on muscle IGFBP mRNA content in young and mature adult male F344 rats

From: Alcohol-induced decrease in muscle protein synthesis associated with increased binding of mTOR and raptor: Comparable effects in young and mature rats

 

Young

Mature – Low Dose EtOH*

Mature – High Dose EtOH

 

Control

Alcohol

Control

Alcohol

Control

Alcohol

IGFBP-3, AU/L32

1.00 ± 0.08

0.87 ± 0.11

0.81 ± 0.12

0.83 ± 0.11

0.79 ± 0.11

0.77 ± 0.15

IGFBP-4, AU/L32

1.00 ± 0.12

0.95 ± 0.12

1.24 ± 0.21

1.18 ± 0.19

1.14 ± 0.12

1.13 ± 0.14

IGFBP-5, AU/L32

1.00 ± 0.06a

0.66 ± 0.06b

0.84 ± 0.07a

0.85 ± 0.06ab

0.89 ± 0.08a

0.49 ± 0.07b

  1. Values are means ± SEM where the sample size was 10, 10, 6, 7, 9, and 9 for the six groups, respectively. *Mature rats were administered either "low" dose alcohol (75 mmol/kg) or "high" dose alcohol (90 mmol/kg); young rats were injected with 75 mmol/kg. The abundance of IGFBP-1, BP-2 and ALS was below the detection limit in muscle for all rats and data are not reported. Values with different letters for a particular hormone are significantly different from each other, P < 0.05. Values with the same letter are not significantly different.
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Nutrition & Metabolism

ISSN: 1743-7075

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