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Table 1 Screening characteristics

From: Differential changes in serum uric acid concentrations in sibutramine promoted weight loss in diabetes: results from four weeks of the lead-in period of the SCOUT trial

  DM only CVD only CVD+DM
  n = 2584 n = 1748 n = 6397
Age (years) 62 (± 6) 64 (± 6) 64 (± 6)
Male gender (%) 38% 66% 64%
BMI (kg/m 2 ) 35.9 (± 4.8) 33.4 (± 4.1) 34.0 (± 4.4)
Weight (kg) 97.4 (± 16.1) 95.0 (± 14.8) 95.8 (± 15.4)
Waist circumference, men (cm) 117 (± 12) 112 (± 10) 114 (± 10)
Waist circumference, women (cm) 111 (± 12) 104 (± 11) 109 (± 11)
Systolic blood pressure (mmHg) 141 (± 12) 136 (± 13) 138 (± 13)
Diastolic blood pressure (mmHg) 78 (± 8) 78 (± 8) 77 (± 9)
Pulse (bpm) 75 (± 10) 68 (± 10) 71 (± 10)
Creatinine clearance (mL/min/1.73 m 2 ) 76 [48;105] 72 [47;99] 71 [41;103]
Uric acid concentration (μmol/L) 342 (± 87) 369 (± 86) 374 (± 98)
Glucose concentration (mmol/L) 9.0 (± 3.1) 6.0 (± 1.0) 8.9 (± 3.2)
HDL cholesterol (mmol/L) 1.3 (± 0.3) 1.2 (± 0.3) 1.2 (± 0.3)
LDL cholesterol (mmol/L) 3.1 (± 0.9) 3.0 (± 0.9) 3.0 (± 1.0)
Triglycerides (mmol/L) 2.2 (± 1.5) 2.0 (± 1.1) 2.4 (± 1.4)
History of dyslipidaemia (%) 71% 76% 86%
History of stroke (%) 0% 9% 12%
Peripherial artery disease (%) 0% 8% 16%
Use of alcohol (%) 51% 63% 54%
Current smokers (%) 11% 10% 9%
Coronary artery disease (%) 4% 87% 83%
CHF (%) 2% 9% 11%
Use of diuretics (%) 45% 37% 51%
Use of Insulin (%) 26% 0.5% 32%
Use of statins (%) 42% 73% 73%
Use of ACE-inhibitors (%) 73% 64% 82%
Use of Ca 2+ -blockers (%) 32% 33% 40%
Use of fibrates (%) 10% 6% 10%
Urinary dip stick for glucose:    
Negative (%) 81% 99% 79%
Trace (%) 6% 0.4% 6%
1+ (%) 4% 0.2% 5%
2+ (%) 3% 0.1% 3%
3+ (%) 6% 0.4% 6%
  1. Continuous variables are presented as means (± standard deviation) and discrete variables as percentages (%). Creatinine clearance is presented as median [5th 95th percentiles] due to widely distributed values. Blood samples were obtained during screening visit, as were medical histories. Weight, BMI, waist circumference, pulse and blood pressure are values from the first day of sibutramine administration.