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Table 1 Recovery of [13C]LA or [13C]ALA after exposure of HepG2 cells to [13C]LA-/[13C]ALA-methylester at ratios of 0:1, 1:1, 4:1, 9:1 and 1:0 for 24 hours. 1not detected, LOD: 0.13 ng/μl.

From: Quantitation of alpha-linolenic acid elongation to eicosapentaenoic and docosahexaenoic acid as affected by the ratio of n6/n3 fatty acids

  LA/ALA 0:1 LA/ALA 1:1 LA/ALA 4:1 LA/ALA 9:1 LA/ALA 1:0
13 C LA administered [μmol] 0 50 80 90 100
   cell culture medium [μmol] n.d.1 7.1 ± 0.75 3.8 ± 0.35 4.5 ± 0.14 7.0 ± 0.37
   cells [μmol] n.d.1 37.6 ± 1.96 66.0 ± 2.51 75.3 ± 1.80 74.6 ± 2.97
   percent administered [%] - 83 84 75 75
13 C ALA administered [μmol] 100 50 20 10 0
   cell culture medium [μmol] 9.0 ± 1.2 4.7 ± 0.27 1.3 ± 0.11 2.1 ± 0.11 n.d.1
   cells [μmol] 65.3 ± 3.90 32.6 ± 2.15 16.41 ± 0.31 6.90 ± 0.17 n.d.1
   Percent administered [%] 65 65 82 69 -