Serum HER-2 concentration is associated with insulin resistance and decreases after weight loss

Nutrition & Metabolism

Table 1 Clinical and biochemical variables of Cohort 1 subjects

	Normal glucose tolerance	Impaired glucose tolerance	Type 2 diabetes	ANOVA p
N	100	38	29	-
Age [years]	50.7 ± 13	59.6 ± 10.2	58 ± 12.1	<0.0001
BMI [kg/m ² ]	26.8 ± 3.3	28.3 ± 3.4	31.8 ± 6.9	<0.0001
Waist [cm]	90.4 ± 8.6	94.3 ± 9.1	104.6 ± 15.3	<0.0001
Systolic blood pressure [mm Hg]	124.7 ± 13	132.4 ± 17.3	138.8 ± 16.4	<0.0001
Diastolic blood pressure [mm Hg]	79 ± 9.1	83 ± 10.4	84.2 ± 11	0.03
Cholesterol [mg/dl]	205.5 ± 40.3	227.4 ± 41.7	211.8 ± 34.8	0.01
LDL-cholesterol [mg/dl]	132.8 ± 37.2	149.2 ± 34.6	129.3 ± 37.8	0.03
HDL- cholesterol [mg/dl]	53 ± 12.4	51.4 ± 11.5	47.3 ± 12	0.09
Log-Triglycerides [mg/dl]	1.94 ± 0.21	2.06 ± 0.21	2.13 ± 0.25	<0.0001
Fasting glucose [mg/dl]	95 ± 9.8	102.3 ± 11.5	138.5 ± 23	<0.0001
Fasting insulin [mU/l]	8 ± 4	12.1 ± 6.2	14.3 ± 9.7	<0.0001
HbA _1c [%]	4.8 ± 0.55	4.9 ± 0.4	5.9 ± 1	<0.0001
120' OGTT glucose [mg/dl]	108.3 ± 19.3	164.4 ± 19.4	233.2 ± 21.7	<0.0001
Log Insulin sensitivity [min ^-1 10 ^-4 mU/L]*	0.58 ± 0.19	0.38 ± 0.17	0.16 ± 0.16	<0.0001
Free IGF-I [ng/ml]	1.51 ± 1.13	1.20 ± 1.05	0.47 ± 0.56^†	<0.0001
HER-2 [ng/ml]	9.6 ± 2.2	10.4 ± 1.8	11.4 ± 1.9^†	<0.0001

Expressed as mean ± SD; *determined in 72 subjects with normal glucose tolerance, 26 with impaired glucose tolerance and 11 with type 2 diabetes.
Post-hoc analyses
^†p < 0.0001 after Sheffé's test compared with subjects with normal glucose tolerance.

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