Dietary fat and bile juice, but not obesity, are responsible for the increase in small intestinal permeability induced through the suppression of tight junction protein expression in LETO and OLETF rats

Table 2 Initial body weight, final body weight, food intake, energy intake, liver weight, and fat pad weight

		Body weights				Food intake	Energy intake	Liver weight	Fat pad weight¹
		0 week	2 weeks	8 weeks	16 weeks
Strain	Diet	g	g	g	g	g/day	cal/day	g/rat	g/rat
LETO	Standard	91.5 ± 1.9 b	189 ± 14 b	365 ± 10 d	461 ± 13 d	18.2 ± 0.4 c	71.9 ± 1.7 d	9.49 ± 0.28 c	25.0 ± 2.4 d
	High fat	89.4 ± 1.3 b	195 ± 2 b	420 ± 6 c	551 ± 28 c	15.8 ± 0.2 d	80.5 ± 1.2 c	9.74 ± 0.34 c	47.2 ± 3.1 c
OLETF	Standard	114 ± 1.9 a	242 ± 3 a	500 ± 6 b	655 ± 35 b	25.1 ± 0.5 a	99.5 ± 1.7 b	17.2 ± 0.67 b	76.1 ± 2.3 b
	High fat	114 ± 1.5 a	258 ± 7 a	606 ± 16 a	769 ± 49 a	22.8 ± 0.4 b	116 ± 2.5 a	22.6 ± 0.81 a	114 ± 4.3 a
2-way ANOVA	Strain	< 0.01	< 0.01	< 0.01	< 0.01	< 0.01	< 0.01	< 0.01	< 0.01
	Diet	0.52	0.03	< 0.01	0.06	< 0.01	< 0.01	< 0.01	< 0.01
	S × D	0.54	0.43	0.12	< 0.01	0.93	0.04	< 0.01	0.92

Each value represents mean ± SEM, n = 9. Means without a common letter differ, P < 0.05.
¹ Fat pad weight: sum of mesenteric, epididymal and retroperitoneal fat pads weights

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