Insulin sensitivity. Chow, HFP, HFL and HFPS fed mice were subjected to hyperinsulinemic-euglycemic clamp analysis. Shown are the insulin sensitivity of the peripheral tissues and the liver. Peripheral insulin sensitivity was expressed as the percentage of increase of glucose disappearance rate (Rd) during the hyperinsulinemic state compared to basal. Hepatic insulin sensitivity was expressed as the percentage of repression of hepatic glucose production compared to basal. N = 5-8 per group. The chow data (checkered bars) were obtained in a separate experiment and are shown for comparison. *; p < 0.05 compared to chow, $; p < 0.05 compared to HFP.