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Table 5 Food intake, body and organ weights, blood glucose and plasma lipids for 5-wk old male Nile rats fed 3 types of diets for 24 wks (Expt 7)

From: Nutritional correlates and dynamics of diabetes in the Nile rat (Arvicanthis niloticus): a novel model for diet-induced type 2 diabetes and the metabolic syndrome

  Diet:
  #1 #2 (Western-type) Chow
  Low-fat, high-fiber High-fat, low-fiber (RMH #3000)
CHO: FAT: Prot %en 69:15:16 40:43:17 60:14:26
Body weight (g)
Initial (5 wks old) 51 ± 3 52 ± 7 55 ± 5
Final (24 wk trial) 110 ± 11 118 ± 19 131 ± 9
Body weight gain (g/d) 0.34 ± 0.06 0.38 ± 0.09 0.41 ± 0.07
Food intake as dry diet (g/d) 22.5 ± 1.5 14.3 ± 1.0 N/A
(kcal/d) 79 ± 5 64 ± 4 N/A
Organ weight (%BW)
   Liver 5.39 ± 0.54a 7.23 ± 1.06a,b 4.48 ± 1.41b
   Kidney 1.26 ± 0.31 1.47 ± 0.33a 0.98 ± 9.30a
   Cecum 3.3 ± 0.9 2.1 ± 1.0 2.1 ± 1.3
   Adipose    
Perirenal* 0.80 ± 0.59 0.73 ± 0.62 1.34 ± 0.53
Epididymal 2.25 ± 0.69a 2.59 ± 0.82 3.33 ± 0.35a
Inguinal 0.73 ± 0.42 0.72 ± 0.25 0.85 ± 0.15
Total (all above) 3.79 ± 1.62 4.04 ± 1.64 5.52 ± 0.98
   Carcass 68 ± 3 68 ± 3 69 ± 4
Initial blood glucose (mg/dl) 61 ± 4 81 ± 13 N/A
Random, 24 wk glucose (mg/dl) 395 ± 149a 276 ± 82 150 ± 82a
Fasting, 24 wk glucoseÁ (mg/dl) 76 ± 17 158 ± 114 118 ± 142
Liver Lipids    
TC (mg/g) 3 ± 1a 15 ± 3a,b 5 ± 2b
TG (mg/g) 18 ± 8a 137 ± 40a,b 35 ± 6b
Plasma (fasting, terminalÁ)
TC (mg/dL) 199 ± 51 568 ± 400a 97 ± 14a
TG (mg/dL) 194 ± 26a 1371 ± 992a,b 203 ± 78b
  1. Values are Mean± SD (n = 4). NA = not available.
  2. a,b,c.. Means in a row sharing a common superscript differ (p < 0.05) using one-way ANOVA and Fisher's PLSD test.
  3. ÁBlood glucose after 16 h fasting. Significantly different (p < 0.05).
  4. *Perirenal represents the perirenal and retroperitoneal fat pool