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Table 5 Food intake, body and organ weights, blood glucose and plasma lipids for 5-wk old male Nile rats fed 3 types of diets for 24 wks (Expt 7)

From: Nutritional correlates and dynamics of diabetes in the Nile rat (Arvicanthis niloticus): a novel model for diet-induced type 2 diabetes and the metabolic syndrome

 

Diet:

 

#1

#2 (Western-type)

Chow

 

Low-fat, high-fiber

High-fat, low-fiber

(RMH #3000)

CHO: FAT: Prot %en

69:15:16

40:43:17

60:14:26

Body weight (g)

Initial (5 wks old)

51 ± 3

52 ± 7

55 ± 5

Final (24 wk trial)

110 ± 11

118 ± 19

131 ± 9

Body weight gain (g/d)

0.34 ± 0.06

0.38 ± 0.09

0.41 ± 0.07

Food intake as dry diet (g/d)

22.5 ± 1.5

14.3 ± 1.0

N/A

(kcal/d)

79 ± 5

64 ± 4

N/A

Organ weight (%BW)

   Liver

5.39 ± 0.54a

7.23 ± 1.06a,b

4.48 ± 1.41b

   Kidney

1.26 ± 0.31

1.47 ± 0.33a

0.98 ± 9.30a

   Cecum

3.3 ± 0.9

2.1 ± 1.0

2.1 ± 1.3

   Adipose

   

Perirenal*

0.80 ± 0.59

0.73 ± 0.62

1.34 ± 0.53

Epididymal

2.25 ± 0.69a

2.59 ± 0.82

3.33 ± 0.35a

Inguinal

0.73 ± 0.42

0.72 ± 0.25

0.85 ± 0.15

Total (all above)

3.79 ± 1.62

4.04 ± 1.64

5.52 ± 0.98

   Carcass

68 ± 3

68 ± 3

69 ± 4

Initial blood glucose (mg/dl)

61 ± 4

81 ± 13

N/A

Random, 24 wk glucose (mg/dl)

395 ± 149a

276 ± 82

150 ± 82a

Fasting, 24 wk glucoseÁ (mg/dl)

76 ± 17

158 ± 114

118 ± 142

Liver Lipids

   

TC (mg/g)

3 ± 1a

15 ± 3a,b

5 ± 2b

TG (mg/g)

18 ± 8a

137 ± 40a,b

35 ± 6b

Plasma (fasting, terminalÁ)

TC (mg/dL)

199 ± 51

568 ± 400a

97 ± 14a

TG (mg/dL)

194 ± 26a

1371 ± 992a,b

203 ± 78b

  1. Values are Mean± SD (n = 4). NA = not available.
  2. a,b,c.. Means in a row sharing a common superscript differ (p < 0.05) using one-way ANOVA and Fisher's PLSD test.
  3. ÁBlood glucose after 16 h fasting. Significantly different (p < 0.05).
  4. *Perirenal represents the perirenal and retroperitoneal fat pool