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Table 6 Food and water intake, body and organ weights, blood glucose and plasma lipids for 20-wk old Nile rats fed chow #5020 ad libitum or restricted to 75% ad libitum for 18 wks (Expt 8)

From: Nutritional correlates and dynamics of diabetes in the Nile rat (Arvicanthis niloticus): a novel model for diet-induced type 2 diabetes and the metabolic syndrome

 

Chow 5020

 

ad libitum

Restricted to 75%

CHO:FAT:Prot %en

57:21:22

57:21:22

Diet: Kcal/g

3.75

3.75

Body weight (g)

  

   Initial (age: 20 wks)

112 ± 20

102 ± 8

   Final after 13 wks

119 ± 23

110 ± 9

   Final after 18 wks

123 ± 21

112 ± 15

   gain/day

0.019 ± 0.007

0.020 ± 0.024

Food intake (g/d)

17.4 ± 6.8

13.0 ± 3.0

   (kcal/d)

65 ± 25

49 ± 11

Water intake (ml/d)

19.9 ± 15.0

20.7 ± 14.4

Organ weight (%BW)

  

   Liver

4.36 ± 0.98

3.40 ± 0.36*

   Kidneys

1.01 ± 0.24

0.89 ± 0.17

   Cecum

1.86 ± 0.5

1.61 ± 0.28

   Adipose

  

Perirenal

1.21 ± 0.54

0.91 ± 0.70

Epididymal

2.26 ± 1.06

2.35 ± 0.70

Inguinal

1.45 ± 0.39

1.15 ± 0.23

Omental

1.09 ± 0.16

0.88 ± 0.29

Suprascapular (brown fat)

3.01 ± 1.18

1.80 ± 0.74

Total (all above)

9.03 ± 2.21

7.10 ± 2.05

   Carcass

68.5 ± 2.86

70.0 ± 3.71

Body Length

13.7 ± 0.9

13.5 ± 0.4

BMI (kg/m2)

6.5 ± 0.3

6.2 ± 0.5

LMI (kg/m2)

4.4 ± 0.3

4.3 ± 0.3

ipGTT at 18 wk

  

0 time

211 ± 152

72 ± 35*

1 hr

517 ± 172

226 ± 135*

Blood glucose (15 h fasting), mg/dL

  

   Initial

56 ± 19

60 ± 41

   After 13 wks

70 ± 21

36 ± 3*

   Final after 18 wks

211 ± 152

72 ± 35*

Plasma lipids (terminal)

  

   TC (mg/dL)

169 ± 68

115 ± 22

   TG (mg/dL)

179 ± 149

56 ± 19

  1. Values are Mean ± SD, (n = 5-6; 2-3 females and 2-4 males per group)
  2. * Significanly different (p < 0.05)