Inverse relation between FASN expression in human adipose tissue and the insulin resistance level

Nutrition & Metabolism

Table 2 Anthropometrical and biochemical characteristics of study subjects: with and without high glycaemia

Patients	Control	High Glycaemia	P
BMI	26.18 ± 4.80	29.51 ± 4.29	0.03
SBP	126.70 ± 18.79	137.75 ± 16.38	0.06
DBP	76.35 ± 10.13	77.50 ± 11.68	0.72
W-H	0.89 ± 0.08	0.91 ± 0.07	0.26
Insulin	12.28 ± 6.29	14.93 ± 8.02	0.20
Glucose	83.78 ± 9.40	136.36 ± 52.61	0.01
HbA1c	5.59 ± 0.38	6.70 ± 0.66	0.00
HOMA-IR	2.56 ± 1.38	5.02 ± 2.50	0.01
Cholesterol	201.43 ± 34.37	194.45 ± 52.35	0.68
TG	105.78 ± 49.68	195.64 ± 113.98	0.03
LDL-c	125.36 ± 26.61	110.91 ± 35.28	0.11
HDL-c	53.81 ± 13.35	49.27 ± 12.10	0.29
CRP	5.75 ± 13.89	3.23 ± 2.58	0.55
Adiponectin	18.94 ± 11.68	14.08 ± 5.68	0.16
Leptin	17.32 ± 17.77	26.83 ± 19.96	0.10
FASN	0.27 ± 0.17	0.08 ± 0.03	0.00
PPARγ1	0.07 ± 0.20	0.03 ± 0.03	0.49
PPARγ2	0.01 ± 0.00	0.01 ± 0.01	0.98

Values are presented as means ± SD. BMI, body mass index (Kg/m²); SBP, systolic blood pressure (mm Hg); DBP, diastolic blood pressure (mm Hg); W-H ratio, waist to hip ratio; Insulin (UI/ml); Glycaemia (mg/dl); HbA1c, glycated haemoglobin (%); HOMA-IR, homeostasis model assessment ((gluc mg/dl*insul U/ml)/405); Cholesterol (mg/dl); TG, triglycerides (mg/dl); LDL-c, low density lipoprotein-cholesterol (mg/dl); HDL-c, high density lipoprotein-cholesterol (mg/dl); CRP, c-reactive protein (mg/l); Adiponectin (ng/ml); Leptin (ng/ml); FASN, fatty acid synthase; PPARγ, peroxisome proliferator-activated receptor. Relationship between variables in control and hyperglycemic individuals was assessed by Student's t test.

ISSN: 1743-7075