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Figure 5 | Nutrition & Metabolism

Figure 5

From: Subchronic exposure to phytoestrogens alone and in combination with diethylstilbestrol - pituitary tumor induction in Fischer 344 rats

Figure 5

Representative stained pituitary tissues from animals treated with DES, daidzein, or the combination: The hematoxylin and eosin staining of pituitary tissues were recorded at 400× magnification from animals treated with A. cholesterol; B. DES; C. daidzein; or D. daidzein + DES. Note the large vascular and hemorrhagic areas (black arrows in B and D) resulting from DES treatments, regardless of whether daidzein (or other phytoestrogens) were administered in combination. Also note the larger nuclear size in animals treated with daidzein + DES (blue arrowheads in D). Combination treatments with DES plus other phytoestrogens gave similar results.

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Nutrition & Metabolism

ISSN: 1743-7075

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