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Table 2 Potential Consensus PDZ Domain Binding Sequences in SR-BI, SR-BII and CD36

From: Cellular cholesterol delivery, intracellular processing and utilization for biosynthesis of steroid hormones

Mouse SR-BI:

QLRSQEKCFLFWSGSKKGSQDKEAIQAYSESLMSPAAKGTVLQEAKL

 

QLRSQEKCFLF WSGSKKGSQDKEAIQA YSESLMSP AAKGTVLQEAKL

Rat SR-BI:

QLRSQEKCFLFW SGSKKGSQDKEAM QAYSWSLMSPAA KGTVL QEAKL

 

QLRSQEKCFLF WSGSKKGSQDKEAMQA YSWSLMSP AAKGTVLQEAKL

Hamster SR-BI:

QLRSQEKCFLFW SGSKKGSQDKEAI QAYAESL MSPAA KGTVL QEAKL

 

QLRSQEKCFLF WSGSKKGSQDKEAIQA YAESLMSP AAKGTVLQEAKL

Rabbit SR-BI:

QVRSQEKCYLFW SGSKKGSKDKEAI QAYSESL MTPDP KGTVL QEARL

 

QVRSQEKCYLFWSGSKKGSKDKEAIQA YSESLMTP DPKGTVLQEARL

Pig SR-BI:

QIRSQEKCYLFW SSSKKGSKDKEAI QAYSESL MTPAP KGTVL QEARL

 

QIRSQEKCYLFWSSSKKGSKDKEAIQA YSESLMTP APKGTVLQEARL

Cow SR-BI:

QIRSQEKCYLFW ISFKKGSKDKEAV QAYSEFL MTSPPKGTVL QEARL

 

QIRSQEKCYLFWISF KKGSKDKEAVQA YSEFLMTSPPKGTVLQEARL

Human SR-BI:

QIRSQEKCYLFW SSSKKGSKDKEAI QAYSESL MTSAPKGSVL QEAKL

 

QIRSQEKCYLFWSSSKKGSKDKEAIQA YSESLMTSAPKGSVLQEAKL

Mouse SR-BII:

QLRSQGPEDTI SPPNLIAWSDQPPSPYTPLLEDSLSGQPTSAMA

 

QLRSQGPEDTISPPNLIAWSDQPPSPYTPLLEDSLSGQPTSAMA

Rat CD36:

RSKNGK-None

  1. PDZ Domain-Class I: S or T-X-I, V, L or M; PDZ Domain-Class II: ψ-X-ψ; PDZ Domain-Class III: D or E -X-ψ. The C-terminal residue is referred to as Po residue; subsequent residues towards the N-terminus are termed P-1, P-2, P-3 etc. X denotes any amino acid (no specificity defined at this position for this class). ψ denotes a hydrophobic amino acid usually V, I or L. The sequences of C-terminal domain of SR-BI, SR-BII and CD36 are presented in duplicates to accomodate 3 letter overlapping combinations of putative PDZ binding sites. The putative PDZ domain binding sequences (three letters) are shown as bold letters.
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Nutrition & Metabolism

ISSN: 1743-7075

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