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Table 5 Plasma amino acid concentrations and indexes at baseline and at 3 and 6 months in elderly patients exclusively receiving a protein-enriched enteral diet

From: A specific protein-enriched enteral formula decreases cortisolemia and improves plasma albumin and amino acid concentrations in elderly patients

Amino Acids (μmol/L)

0 mo

3 mo

6 mo

P*

Aliphatic amino acids

    

   Alanine

317 ± 33

315 ± 39

342 ± 32

.607

   Glycine

143 ± 18

183 ± 20

208 ± 18

.168

Branched-chain amino acids

    

   Isoleucine

38 ± 4

41 ± 6

52 ± 3

.062

   Leucine

68 ± 8a

57 ± 6a

96 ± 6b

.002

   Valine

146 ± 22ab

130 ± 12a

178 ± 12b

.007

Hydroxyl amino acids

    

   Threonine

87 ± 10a

132 ± 20b

150 ± 17b

.001

   Serine

75 ± 7

77 ± 10

83 ± 7

.449

Sulfur amino acids

    

   Taurine

7 ± 1a

11 ± 3b

102 ± 11c

<.001

   Cysteine

20 ± 5a

25 ± 8a

68 ± 6b

<.001

   Methionine

24 ± 7a

59 ± 8b

24 ± 1a

.002

Acidic amino acids and amides

    

   Glutamic Acid

47 ± 7

46 ± 8

46 ± 8

.766

   Glutamine

454 ± 64a

500 ± 102a

968 ± 123b

.001

   Aspartic Acid

7 ± 1

7 ± 1

6 ± 1

.189

   Asparagine

43 ± 8a

21 ± 6a

71 ± 6b

.001

Aromatic amino acids

    

   Phenylalanine

36 ± 5a

37 ± 4a

51 ± 3b

.015

   Tyrosine

40 ± 4a

38 ± 4a

56 ± 5b

.017

Basic amino acids

    

   Arginine

30 ± 4a

44 ± 6ab

54 ± 5b

.005

   Citrulline

31 ± 7a

25 ± 5a

46 ± 4b

.006

   Histidine

81 ± 14a

130 ± 13b

85 ± 5a

.022

   Lysine

86 ± 12

114 ± 16

91 ± 5

.189

   Ornithine

77 ± 14

99 ± 21

83 ± 7

.549

   Imino acids

    

   Hydroxyproline

12 ± 2

14 ± 2

8 ± 1

.257

   Proline

190 ± 25a

128 ± 13b

194 ± 21a

.046

Amino Acid Indexes

    

   NEAA/EAA

2.54 ± 0.14a

2.34 ± 0.52b

2.93 ± 0.20a

.008

   BCAA (μmol/L)

256 ± 32a

228 ± 16a

326 ± 21b

.007

   Alanine/Threonine

3.85 ± 0.40a

3.93 ± 0.41ab

2.56 ± 0.31b

.017

   Glycine/Valine

1.09 ± 0.15

2.12 ± 0.62

1.23 ± 0.12

.420

   Alanine/Leucine

4.85 ± 0.40a

5.78 ± 0.66a

3.59 ± 0.27b

.004

   Alanine/BCAA

1.36 ± 0.15ab

1.35 ± 0.13a

1.05 ± 0.07b

.017

   Phenylalanine/Tyrosine

0.92 ± 0.07

1.00 ± 0.06

0.96 ± 0.05

.449

   Cysteine/Methionine

1.46 ± 0.41a

0.88 ± 0.40a

2.80 ± 0.20b

.001

   H Index

2.25 ± 0.22

2.52 ± 0.21

1.98 ± 0.13

.071

   Whitehead Index

2.66 ± 0.25a

2.50 ± 0.35a

4.15 ± 0.43b

<.001

  1. NEAA, nonessential amino acids; EAA, essential amino acids; BCAA, branched-chain amino acids; H Index, relationship between the sum of serine, glycine, and alanine concentrations and the BCAA concentration; Whitehead Index, relationship between the sum of serine, glycine, glutamine, and taurine concentrations and the sum of methionine and BCAA concentrations. Tryptophan concentrations are not reported, because much of this amino acid is bound to plasma proteins, which are eliminated during the deproteinization step in the analytical procedure
  2. * Differences among sample times were tested using Friedman test for three repeated measures, considering P < 0.05 to be significant.
  3. x ± SEM (for all values)
  4. ‡ Differences between times were analyzed using the Wilcoxon test, considering P < 0.05 to be significant. In each group, mean values within the same row with unlike superscript letters were significantly different.