Restricted food intake more effectively attenuates obesity-induced insulin resistance and glucose intolerance than exercise. (A) Glucose tolerance test (GTT) was performed in mice that were subjected to food restriction versus exercise for 8 weeks and (B) the area under curve (AUC) for GTT was determined for each group. (C) Fasting plasma insulin levels. Data are shown as means ± SEM (n = 6/group). Statistical analyses were done with one-way ANOVA. *p < 0.05, **p < 0.01 vs. LC; #p < 0.05, ##p < 0.01 vs. HC; ΔΔp < 0.01 vs. HRE.