Rx significantly reduced the secretion of cytokines in human THP-1 macrophages. Panels show (a) MCP-1, (b) IL-6 and (c) TNF-α concentrations in human THP-1 macrophage conditioned medium after incubation with Rosiglitazone (10 μg/ml) or Rx (5 μg/ml or 10 μg/ml) for 48 hours. Each bar represents the relative mean fold change ± SEM (n = 6). Data were statistically analyzed using the one-way ANOVA with Dunnette's post hoc test. * P < 0.05; ** P < 0.01.