Rx decreased both fed and fasting blood glucose levels and alleviated hypertriglyceridemia in db/db diabetic mice. Male db/db diabetic mice were treated with vehicle or Rx (2 g/kg/day) for 12 weeks by oral gavage. (a) The weekly profile of fed glucose levels. (b) The fasting glucose levels at week 2, 6 and 12 measured after 16 hours of starvation. (c) Fasting serum insulin concentration after 12 weeks of Rx treatment. (d) The weekly profile of fed triglyceride level. (e) Serum free fatty acid concentration after 12 weeks of Rx treatment. Data were statistically analyzed using one-way ANOVA with Dunnette's post hoc test. Data are presented as mean ± S.E.M. (n = 5-6). ** P < 0.01.