Rx inhibited the inflammatory state in adipose tissue of db/db diabetic mice. Panels show the relative mRNA levels of the inflammatory cell markers (a) CD68 and (b) F4/80, pro-inflammatory cytokines (c) TNF-α and (d) MCP-1 and alternatively activated macrophage marker (e) arginase I in adipose tissue of vehicle- or Rx-treated db/db diabetic mice and lean control. Data were statistically analyzed using one-way ANOVA with Dunnette's test. Data are presented as relative mean fold change ± S.E.M. (n = 5-6). * P < 0.05; ** P < 0.01.