Figure 2

Daily food intake (A1, in males and A2, in females) and cumulative caloric intake (B) from weaning at the age of 21 days until the age of 5 months (TOTAL), as well as during the last month under NF diet (from 3 to 4 months old) (NF) and when animals were exposed to HF diet (from 4 to 5 months old) (HF) of male and female offspring of controls and caloric restricted dams during gestation (CR). The percentage increase in food intake of CR compared with controls is indicated in brackets. Animals were fed with standard normal fat (NF) diet until the age of 4 months and then exposed to a high fat (HF) diet (the dotted line indicates the time point of change from NF to HF diet). Data are expressed as the mean ± SEM of 12 animals per group. Statistics: RxA, interaction between caloric restriction during lactation and age (ANOVA repeated measures). ^#, different from their respective control group (Student's t test). The arrow indicates the starting point of significant effects on body weight in male animals.