HOMA-IR index of male and female offspring of controls and caloric restricted dams during gestation (CR) at the ages of 2, 4 and 5 months. Animals were fed with standard normal fat (NF) diet until the age of 4 months and then exposed to a high fat (HF) diet. Data are mean ± S.E.M. (n = 8). Statistics: R, effect of caloric restriction; S, effect of sex (two way ANOVA). #, different from their respective control group (Student's t test).