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Table 1 Relationship at metabolic pathway level between the ketogenic-diet map and type 2 diabetes

From: Revealing the molecular relationship between type 2 diabetes and the metabolic changes induced by a very-low-carbohydrate low-fat ketogenic diet

Ketogenic-diet map Pathophysiological pathways of Type 2 Diabetes  
Presence Insufficient insulin production Insulin resistance
% effector proteins present in ketogenic-diet map (No. protein present/Total No. in data base) 23% (7/30) 56% (13/23)
Distance to ketogenic pathways (Hausdorff distance) Insufficient insulin production Insulin resistance
Fatty acid metabolism (KEGG: HSA00071) (No. of jumps, minimum distance) 2.3 (0.95) 2.5 (0.85)
Synthesis and degradation of ketone bodies (KEGG: HSA00072) (No. of jumps, minimum distance) 2.3 (0.95) 2.5 (0.85)
  1. Values in brackets report the significance of the distance value. It has been estimated from the distribution of the Hausdorff distances of all pathophysiological conditions contained in ax_SafetyDB to pathways (path 71 and 72). The same principles as the ones described in figure 2 have been applied.