Table 2 Direct relationships (1 jump) between seed proteins of ketogenic-diet map and type 2 diabetes effector proteins.
Physiologic Pathway | Type 2 Diabetes Effector Protein (Protein Name) | Gene Name (synonyms) |
|---|---|---|
Insufficient insulin production | Somatotropin | GH1 |
Solute carrier family 2, facilitated glucose transporter member 4 (GLUT4) | SLC2A4 (GLUT4) | |
E3 ubiquitin-protein ligase CBL (CBL) | CBL (CBL2, RNF55) | |
Protein kinase C alpha type (PRKCA) | PRKCA (PKCA, PRKACA) | |
Insulin resistance | Nuclear factor NF-kappa-B p105 subunit (NFKβ) | NFKB1 |
Insulin receptor substrate 1 (IRS-1) | IRS1 | |
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1-α) | PPARGC1A (LEM6, PGC1, PGC1A, PPARGC) | |
Protein kinase Akt-3 (PKBγ) | AKT3 (PKBG) |