Revealing the molecular relationship between type 2 diabetes and the metabolic changes induced by a very-low-carbohydrate low-fat ketogenic diet

Table 2 Direct relationships (1 jump) between seed proteins of ketogenic-diet map and type 2 diabetes effector proteins.

Physiologic Pathway	Type 2 Diabetes Effector Protein (Protein Name)	*Gene Name (synonyms)*
Insufficient insulin production	Somatotropin	GH1
	Solute carrier family 2, facilitated glucose transporter member 4 (GLUT4)	SLC2A4 (GLUT4)
	E3 ubiquitin-protein ligase CBL (CBL)	CBL (CBL2, RNF55)
	Protein kinase C alpha type (PRKCA)	PRKCA (PKCA, PRKACA)
Insulin resistance	Nuclear factor NF-kappa-B p105 subunit (NFKβ)	NFKB1
	Insulin receptor substrate 1 (IRS-1)	IRS1
	Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1-α)	PPARGC1A (LEM6, PGC1, PGC1A, PPARGC)
	Protein kinase Akt-3 (PKBγ)	AKT3 (PKBG)

ISSN: 1743-7075