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Table 1 Golden-Syrian hamsters fed cholesterol and SFA-supplemented non-purified diets compared to chow.

From: Use of hamster as a model to study diet-induced atherosclerosis

        

Chow

mg/dL

  

SFA

mg/dL

  

Ref

Strain

Age (weeks)

Study Length (weeks)

% Fat (w/w)

% CH (w/w)

HDL-C

nHDL-C

nHDL-C:HDL-C

TG

HDL-C

nHDL-C

nHDL-C:HDL-C

TG

Lesion

Lesion Measure

[38]

F1B

8

5

101

0.05

   

150

   

650

↑

Aorta stained (μ2)

[31]

F1B

8

8

102

0.05

58

58

1.0

87

88

234

2.7

216

↑

Foam cells/mm2 aorta

[55]

F1B

8

12

103

0.1

48

35

0.7

110

67

444

6.6

545

↔

CE (ug)/aorta (mg wet weight)

[55]

CR

8

12

103

0.1

68

67

1.0

129

86

210

2.4

195

↑

CE (ug)/aorta (mg wet weight)

[49]

CR

10

24

53

2

50

47

0.9

186

247

581

2.4

1912

↑

Fatty streak area (%)

[47]

CR

8

6

102

0.1

71

25

0.4

219

108

112

1.0

341

↔

Aorta with lesion (% )

[47]

CR

8

6

103

0.1

71

25

0.4

219

108

174

1.6

301

↔

Aorta with lesion (% )

[58]

UNK

3-4

28

53

1

   

120

   

169

↔

EC (ug)/aorta (10mg dry weight)

[50]

UNK

5

40

102

0.3

87

64

0.7

102

153

224

1.5

295

↑

Fatty streak area (%)

  1. SFA: saturated fatty acid; CH: cholesterol; HDL-C: high-density lipoprotein cholesterol; nHDL-C: non-HDL-C; TG: triglycerides; CR: Charles River; UNK: unknown hamster strain; EC: esterified cholesterol. SFA source: 1Hydrogenated coconut oil, 2Coconut oil and 3Butter
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Nutrition & Metabolism

ISSN: 1743-7075

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