Table 2 Cortical and trabecular parameters measured by pQCT from the distal metaphysis of mouse femur dissected after 21-week intervention

C (n = 10)

CR (n = 10)

HF (n = 9)

HFR (n = 9)

Diet

Running

Diet*Running

6.80 (0.15)

6.61 (0.28)

7.19 (0.25)^ab

7.18 (0.35)^a

<0.01

0.252

0.291

2.85 (0.14)

2.68 (0.18)

3.11 (0.31)^b

3.16 (0.35)^b

<0.01

0.491

0.190

505 (13)

492 (13)

489 (14)

478 (20)^a

<0.01

<0.05

0.806

1.44 (0.07)

1.32 (0.09)^a

1.52 (0.11)^b

1.51 (0.15)^b

<0.01

0.077

0.114

Biomechanics

867 (71)

763 (113)

1025 (124)^ab

1001 (171)^b

<0.01

0.129

0.336

255 (26)

219 (25)

298 (45)^b

295 (65)^b

<0.01

0.179

0.268

1125 (95)

982 (134)

1323 (164)^ab

1294 (233)^b

<0.01

0.120

0.300

6.77 (0.46)

5.87 (0.55)^a

6.79 (0.53)

6.81 (0.73)

<0.05

<0.05

<0.05

Cortex

1.23 (0.11)

1.06 (0.09)^a

1.21 (0.09)^b

1.17 (0.11)

0.142

<0.01

0.062

779 (11)

757 (23)

770 (19)

752 (31)^a

0.332

<0.01

0.820

0.95 (0.09)

0.80 (0.08)^a

0.93 (0.07)^b

0.88 (0.12)

0.334

<0.01

0.096

139 (23)

110 (14)^a

129 (12)^b

120 (18)^a

0.866

<0.01

0.103

Trabeculae

1.63 (0.11)

1.62 (0.12)

1.90 (0.26)^ab

1.99 (0.32)^ab

<0.01

0.596

0.522

298 (11)

317 (10)^a

308 (12)

314 (12)^a

0.431

<0.01

0.113

0.49 (0.04)

0.51 (0.04)

0.58 (0.08)^a

0.63 (0.10)^ab

<0.01

0.121

0.888

0.28 (0.06)

0.29 (0.05)

0.36 (0.10)

0.28 (0.10)

0.261

0.235

0.147