Figure 6

An integrated view of the metabolic processes (fatty acid biosynthesis, glycolysis, gluconeogenesis and amino acid metabolism) that converge on the citric acid cycle. Red stars represent lysine-acetylated metabolic enzymes and the red box highlights the critical metabolic products integrated into various metabolic pathways. Highlighted enzymes with their respective EC numbers are: pyruvate dehydrogenase (EC 1.2.4.1), dihydrolipoyl dehydrogenase (EC 1.8.1.4), pyruvate carboxylase (EC 6.4.1.1), malate dehydrogenase (EC 1.1.1.37), fumarate hydratase (EC 4.2.1.2), citrate (Si)-synthase (EC 2.3.3.1), ATP citrate synthase (EC 2.3.3.8), aconitate hydratase (EC 4.2.1.3), isocitrate dehydrogenase (NADP⁺) (1.1.1.42), isocitrate dehydrogenase (NAD⁺) (1.1.1.41), succinate dehydrogenase (1.3.5.1), succinate--CoA ligase (6.2.1.4; GDP forming), and succinate--CoA ligase (6.2.1.5; ADP forming).