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Figure 1 | Nutrition & Metabolism

Figure 1

From: A role for pancreatic beta-cell secretory hyperresponsiveness in catch-up growth hyperinsulinemia: Relevance to thrifty catch-up fat phenotype and risks for type 2 diabetes

Figure 1

Rat model of catch-up fat and hyperinsulinemia. Panels a and b show data (mean ± SE, n = 6) for body weight and body fat, respectively, at the end of semistarvation (corresponding to day 0 of refeeding), and at day 7 and 14 of refeeding in refed and control groups consuming isocaloric amounts of food. After sacrifice, the whole carcasses were dried to a constant weight in an oven maintained at 70°C and subsequently homogenized for analysis of fat content by the Soxhlet extraction method as previously described (8). No between-group differences are found in dry lean tissue mass at all time-points; ** p < 0.01; *** p < 0.001. Panels c and d show data (mean ± SE, n = 6) for plasma glucose and insulin before and after an intraperitoneal glucose tolerance test (GTT), which was performed as previously described (8) on day 7 of refeeding, by ip administration of 2 g glucose /kg body weight. Plasma glucose was determined using a Beckman glucose analyzer, while plasma insulin was assessed using rat insulin ELISA kit (Crystal Chem Inc, IL, USA); **: p < 0.01

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