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Table 11 Secondary Plasma Amino Acids and their metabolites, in units of μmol/dl

From: Nutritional and metabolic status of children with autism vs. neurotypical children, and the association with autism severity

Amino Acids Autism Group Neuro-typical Group % Difference p-value Neuro-typical Ref. Range (10th and 90th percentiles) Autism Group % below RR Autism Group % above RR
1-Methyl histidine 0.365
+/- 0.15 		0.355
+/- 0.12 		  n.s. 0.19-0.52 11% 15%
3-Methyl histidine 0.74
+/- 0.68 		0.68
+/- 0.52 		  n.s. 0.20-1.4 13% 20%
Alpha-amino adipate
(33%/27% below dl) 		0.079
+/- 0.32 		0.088
+/- 0.044 		  n.s. 0.05-0.17 0% 0%
Alpha-amino-N-butyrate 1.78
+/- 0.66 		1.82
+/- 0.72 		  n.s. 1.0-2.8 11% 7%
Anserine
(85%/95% below dl) 		0.058
+/- 0.027 		0.051
+/- 0.006 		  0.06 0.32-1.0 11% 11%
Beta-alanine 0.60
+/- 0.28 		0.62
+/- 0.31 		  n.s. 0.05-0.26 0% 15%
Beta-amino isobutyrate 0.191
+/- 0.89 		0.138
+/- 0.088 		+39% 0.004 2.45-3.75 25% 20%
Carnosine
(76%/89% below dl) 		0.061
+/- 0.031 		0.054
+/- 0.015 		  n.s. 2.4-4.3 15% 11%
Citrulline 3.02
+/- 0.80 		3.02
+/- 0.52 		  n.s. 0.31-1.55 9% 18%
Cystine + Cysteine 3.22
+/- 0.82 		3.48
+/- 0.74 		  n.s. 1.3-3.6 5% 5%
Ethanolamine 1.07
+/- 0.75 		0.94
+/- 0.63 		  n.s. 0.13-0.65 2% 9%
Gamma-amino butyrate
(75%/84% below dl) 		0.053
+/- 0.006 		0.053
+/- 0.008 		  n.s. 3.9-8.3 9% 5%
Homocystine + Homocysteine
(71%/89% below dl) 		0.0094
+/- 0.010 		0.0055
+/- 0.0016 		+71% 0.006 0.87-2.2 25% 13%
Hydroxy proline 2.40
+/- 0.80 		2.19
+/- 0.80 		  n.s. 0.0085-0.022 5% 33%
Methionine Sulfoxide 0.368
+/- 0.20 		0.315
+/- 0.21 		  n.s. 0.4-1.35 13% 5%
Ornithine 5.9
+/- 1.6 		5.98
+/- 1.7 		  n.s. 5.3-23.5 4% 4%
Phospho ethanol amine 1.34
+/- 0.73 		1.55
+/- 0.59 		  n.s. 195-400 2% 3%
Phospho serine 0.045
+/- 0.078 		0.024
+/- 0.044 		  n.s.    
Sarcosine 0.80
+/- 0.32 		0.893
+/- 0.36 		  n.s.    
Taurine 13.9
+/- 5.8 		16.8
+/- 5.8 		-17% 0.02    
Urea 299
+/- 94 		309
+/- 87 		  n.s.    
  1. In some cases data was below the detectable limit -if this was greater than 20%, then we report the data as the % of the autism group and then the % of the neurotypical group below the detectable limit (dl).
  2. The table also lists the reference range of the neurotypical group (10th and 90th percentiles), and the % of the Autism group who are above or below the reference ranges. Note that if the groups were identical, 10% would be above and 10% would be below. Percentages above 25% are highlighted.
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Nutrition & Metabolism

ISSN: 1743-7075

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