Time-course changes in blood glucose (A) and 24 h urine protein (B). Blood glucose as well as 24 h urine protein increased progressively in the untreated diabetic rats following induction of diabetes. Curcumin treatment significantly reduced blood glucose and 24 h urine protein in the beginning of treatment and these were maintained throughout the study period until sacrifice. Values are means ± SEM. **p < 0.01 vs Curcumin.