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Table 5 Studies outlining the effects of supplementing dietary arachidonic acid on changes in plasma/serum phospholipid arachidonic acid level

From: Increasing dietary linoleic acid does not increase tissue arachidonic acid content in adults consuming Western-type diets: a systematic review

Author, (reference) Study design Subjects Diet length AA source, amount supplemented (g/d) Δ AA (%) change Comments
Sinclair [54] Parallel intervention N = 4 7 days White meat/eggs (0.50) 52 (p < 0.05) Consumed AA rich, low fat diet
Ishikura [55] Double-blind crossover N = 25 1 month SUNTGA40S capsules (0.72) 27 (p < 0.05) Derived from Mortierella alpina
Theis [45] Randomized, double-blind, parallel intervention N = 48 12 weeks ARASCO (0.68) 85 (p < 0.05) Derived from Mortierella alpina
Kusmoto [56] Double-blind intervention N = 12 4 weeks SUNTGA40S (0.84) 45 (p < 0.05) Derived from Mortierella alpina
Nelson [57] Single blind crossover intervention N = 10 50 days ARASCO (1.49) 85 (p < 0.05) Had 65 day washout period. Derived from Mortierella alpina
Seyberth [58] Single blind intervention N = 4 2-3 weeks, depending upon subject Capsules, AA ethyl ester (6.00) 136 (p < 0.05) Averaged from all 4 subjects
  1. Percent change (±) from baseline in AA that is significant is identified with (p < 0.05). Percent change (±) from baseline in AA that is not significant is denoted by N.S.
  2. Abbreviations: AA, arachidonic acid