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Figure 2 | Nutrition & Metabolism

Figure 2

From: Dietary cholesterol, female gender and n-3 fatty acid deficiency are more important factors in the development of non-alcoholic fatty liver disease than the saturation index of the fat

Figure 2

Plasma and liver parameters of low-fat diets without or with supplemented cholesterol. Plasma levels of cholesterol (panel A), triglycerides (panel B), and NEFA (panel C) in WT and APOE2ki mice fed the respective diets. Panel D depicts the FPLC analysis of plasma lipoproteins of male APOE2ki mice. The plasma lipoprotein profiles of female APOE2ki mice were similar of those in male mice. The concentration of enzymatically measured liver triglycerides is shown in panel E. Panel F represents the macrophage activation score on a scale of 0 to 3 (see additional file 2, table S2: Cd11b-scoring criteria) based on the presence of Cd11b-positive cells in the liver of the mice. Median values of all observations of each group are indicated by diamonds (male mice) and circles (female mice) (red: WT, blue: APOE2ki). The error bars represent the first and third quartiles of each group, *P < 0.05 between the diets. Cd68 mRNA expression is depicted in panel G, Tnf-α expression in panel H, and Ccl2 expression in panel I. Levels are normalized with 18S rRNA. Values in panels A, B, C, E, G, H, I are shown as means ± SEM of 6-10 mice per group, * P < 0.05.

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Nutrition & Metabolism

ISSN: 1743-7075

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