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Table 1 Anthropometric, biochemical, and metabolic parameters of the studied groups

From: Fasting plasma chenodeoxycholic acid and cholic acid concentrations are inversely correlated with insulin sensitivity in adults

 

Control

Obese

T2D

n

14

22

20

Age (yr)

45 [41;59]

49 [20;60]

55 [40;63]#,$

Gender (males/females)

5/9

20/2

12/8

BMI (kg/m2)

23.85 [21.20;32.40]

33.60 [27.90;38.50] *

31.85 [22.80;39.10]#

Fasting glucose (mg/dl)

5.03 [4.50;5.85]

5.50 [4.30;6.80] *

7.37 [5.11;12.50]#,$

HbA1c (%)

5.40 [5.00;5.90]

5.45 [4.80;6.50]

7.40 [5.80;11.70]#,$

Fasting insulin (μUI/ml)

5.90 [2.90;13.90]

11.55 [3.90;35.70] *

11.65 [2.10;38.40]#

HOMA

1.33 [0.60;3.03]

3.15 [0.85;10.79]

3.85 [0.66;16.38]#

BMR (kcal/24 h)

1368 [1066;1920]

1895 [1590;2350] *

1701 [1264;2062]#,$

TC (mg/dl)

209 [170;292]

201[138;250]

184 [104;219]#

TG (mg/dl)

90 [51;187]

140 [62;531] *

130 [44;335]

LDL-C (mg/dl)

122 [86;178]

131 [92;165]

112 [35;139]#,$

HDL-C (mg/dl)

66 [40;103]

40 [26;54] *

46 [37;74]#,$

Total BA (μmol/l)

1.06 [0.46;1.90]

1.49 [0.64;4.06]*

1.34 [0.53;5.54]

DCA (μmol/l)

0.38 [0.14;1.02]

0.44 [0.03;1.07]

0.62 [0.11;1.66]#

CDCA (μmol/l)

0.36 [0.09;1.25]

0.60 [0.31;2.38]

0.43 [0.09;2.78]

CA (μmol/l)

0.22 [0.08;0.50]

0.35 [0.09;1.20] *

0.26 [0.1;1.10]

  1. Data represent median [min;max]. Total BA represent the sum of DCA + CDCA + CA.
  2. Tukey test was used for comparison of clinical parameters between the groups. Statistically significant differences (p < 0.05) are shown between controls and obeses (*), control and type 2 diabetics (#), and obeses and type 2 diabetics ($).
  3. HOMA: homeostasis model assessment (= glucose × insulin/22.5), BMR: basal metabolic rate, TC: total cholesterol, TG: triglycerides, DCA: deoxycholic acid, CDCA: chenodeoxycholic acid, CA: cholic acid.