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Table 5 Levels of N-arachidonoylphosphatidylethanolamine (NArPE), N-palmitoylphosphatidyl-ethanolamine (NPPE) and N-oleoylphosphatidylethanolamine (NOPE) in the liver, gastrocnemius mucle, heart, epididymal and inguinal adipose tissue and kidneys of high-fat fed mice with dietary krill oil (HFKO) supplementation

From: Effect of dietary krill oil supplementation on the endocannabinoidome of metabolically relevant tissues from high-fat-fed mice

Tissue and NAPEs

N (pmol/mg)

HF (pmol/mg)

HFKO1.25 (pmol/mg)

HFKO2.5 (pmol/mg)

HFKO5 (pmol/mg)

Liver

     

NPPE

1.2 ± 0.1

1.2 ± 0.1

1.7 ± 0.2

1.3 ± 0.1

2.0 ± 0.08**

NOPE

0.3 ± 0.02

0.4 ± 0.06

0.5 ± 0.06

0.3 ± 0.02

0.5 ± 0.04*

NArPE

0.2 ± 0.02

0.2 ± 0.06

0.2 ± 0.02

0.2 ± 0.03

0.2 ± 0.03

Gastrocnemius

     

NPPE

1.1 ± 0.2

1.1 ± 0.08

0.9 ± 0.05

0.9 ± 0.09

0.7 ± 0.2

NOPE

0.8 ± 0.1

0.6 ± 0.04

0.5 ± 0.06

05 ± 0.06

0.4 ± 0.07

NArPE

0.3 ± 0.06

0.3 ± 0.05

0.1 ± 0.02*

0.06 ± 0.02**

0.04 ± 0.01**

Heart

     

NPPE

1.7 ± 0.05

1.7 ± 0.2

1.8 ± 0.2

1.6 ± 0.1

1.5 ± 0.1

NOPE

0.2 ± 0.02

0.3 ± 0.01

0.3 ± 0.04

0.3 ± 0.03

0.2 ± 0.03

NArPE

0.2 ± 0.03

0.3 ± 0.05

0.2 ± 0.01

0.2 ± 0.03

0.1 ± 0.02**

Epididymal adipose tissue

     

NPPE

3.6 ± 0.5

3.7 ± 1.2

1.6 ± 0.2

2.5 ± 0.4

1.9 ± 0.5

NOPE

2.9 ± 0.3

1.2 ± 0.1###

0.9 ± 0.2

1.1 ± 0.2

1.1 ± 0.3

NArPE

0.1 ± 0.02

0.3 ± 0.09#

0.07 ± 0.01*

0.1 ± 0.07*

0.04 ± 0.01*

Inguinal adipose tissue

     

NPPE

2.8 ± 0.5

3.3 ± 0.8

2.1 ± 0.6

2.0 ± 0.4

1.5 ± 0.6

NOPE

3.1 ± 0.6

4.2 ± 1.1

2.3 ± 0.7

2.3 ± 0.4

1.6 ± 0.7

NArPE

0.3 ± 0.09

0.6 ± 0.2

0.4 ± 0.1

0.4 ± 0.03

0.3 ± 0.07

Kidney

     

NPPE

1.2 ± 0.2

1.4 ± 0.2

1.4 ± 0.1

1.2 ± 0.12

1.1 ± 0.1

NOPE

1.1 ± 0.2

0.9 ± 0.2

0.8 ± 0.06

0.6 ± 0.05

0.5 ± 0.06

NArPE

1.1 ± 0.2

1.7 ± 0.2

1.0 ± 0.06

0.6 ± 0.7

0.5 ± 0.06

  1. Data are means ± SEM of separate determinations in N = 4-5 mice. # P < 0.05, ## P < 0.01 and ### P < 0.001 N vs HF; * P < 0.05, **P < 0.01 and *** P < 0.001 HF vs HFKO1.25-2.5-5.