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Table 5 Levels of N-arachidonoylphosphatidylethanolamine (NArPE), N-palmitoylphosphatidyl-ethanolamine (NPPE) and N-oleoylphosphatidylethanolamine (NOPE) in the liver, gastrocnemius mucle, heart, epididymal and inguinal adipose tissue and kidneys of high-fat fed mice with dietary krill oil (HFKO) supplementation

From: Effect of dietary krill oil supplementation on the endocannabinoidome of metabolically relevant tissues from high-fat-fed mice

Tissue and NAPEs N (pmol/mg) HF (pmol/mg) HFKO1.25 (pmol/mg) HFKO2.5 (pmol/mg) HFKO5 (pmol/mg)
Liver      
NPPE 1.2 ± 0.1 1.2 ± 0.1 1.7 ± 0.2 1.3 ± 0.1 2.0 ± 0.08**
NOPE 0.3 ± 0.02 0.4 ± 0.06 0.5 ± 0.06 0.3 ± 0.02 0.5 ± 0.04*
NArPE 0.2 ± 0.02 0.2 ± 0.06 0.2 ± 0.02 0.2 ± 0.03 0.2 ± 0.03
Gastrocnemius      
NPPE 1.1 ± 0.2 1.1 ± 0.08 0.9 ± 0.05 0.9 ± 0.09 0.7 ± 0.2
NOPE 0.8 ± 0.1 0.6 ± 0.04 0.5 ± 0.06 05 ± 0.06 0.4 ± 0.07
NArPE 0.3 ± 0.06 0.3 ± 0.05 0.1 ± 0.02* 0.06 ± 0.02** 0.04 ± 0.01**
Heart      
NPPE 1.7 ± 0.05 1.7 ± 0.2 1.8 ± 0.2 1.6 ± 0.1 1.5 ± 0.1
NOPE 0.2 ± 0.02 0.3 ± 0.01 0.3 ± 0.04 0.3 ± 0.03 0.2 ± 0.03
NArPE 0.2 ± 0.03 0.3 ± 0.05 0.2 ± 0.01 0.2 ± 0.03 0.1 ± 0.02**
Epididymal adipose tissue      
NPPE 3.6 ± 0.5 3.7 ± 1.2 1.6 ± 0.2 2.5 ± 0.4 1.9 ± 0.5
NOPE 2.9 ± 0.3 1.2 ± 0.1### 0.9 ± 0.2 1.1 ± 0.2 1.1 ± 0.3
NArPE 0.1 ± 0.02 0.3 ± 0.09# 0.07 ± 0.01* 0.1 ± 0.07* 0.04 ± 0.01*
Inguinal adipose tissue      
NPPE 2.8 ± 0.5 3.3 ± 0.8 2.1 ± 0.6 2.0 ± 0.4 1.5 ± 0.6
NOPE 3.1 ± 0.6 4.2 ± 1.1 2.3 ± 0.7 2.3 ± 0.4 1.6 ± 0.7
NArPE 0.3 ± 0.09 0.6 ± 0.2 0.4 ± 0.1 0.4 ± 0.03 0.3 ± 0.07
Kidney      
NPPE 1.2 ± 0.2 1.4 ± 0.2 1.4 ± 0.1 1.2 ± 0.12 1.1 ± 0.1
NOPE 1.1 ± 0.2 0.9 ± 0.2 0.8 ± 0.06 0.6 ± 0.05 0.5 ± 0.06
NArPE 1.1 ± 0.2 1.7 ± 0.2 1.0 ± 0.06 0.6 ± 0.7 0.5 ± 0.06
  1. Data are means ± SEM of separate determinations in N = 4-5 mice. # P < 0.05, ## P < 0.01 and ### P < 0.001 N vs HF; * P < 0.05, **P < 0.01 and *** P < 0.001 HF vs HFKO1.25-2.5-5.