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Table 4 Effect of diet on fatty acid composition of liver of different mice lines

From: Metabolic responses to high-fat diets rich in n-3 or n-6 long-chain polyunsaturated fatty acids in mice selected for either high body weight or leanness explain different health outcomes

  DU6 DUhTP
  Standard chow n-3 HFD n-6 HFD Standard chow n-3 HFD n-6 HFD
  LSM ± SE LSM ± SE LSM ± SE LSM ± SE LSM ± SE LSM ± SE
SFA+ 2420 ± 222 2794 ± 251 2981 ± 210 1889 ± 222 2520 ± 210 2224 ± 222
C14:0 23·2 ± 8a 73·1 ± 9b 41·2 ± 7a, b 20·0 ± 8a 77·7 ± 7b 23·4 ± 8a
C16:0 1888 ± 186 2057 ± 211 2292 ± 177A 1335 ± 186 1721 ± 177 1351 ± 186B
C18:0 435·3 ± 33 560·1 ± 38 547·5 ± 32A 436·3 ± 33a 589·5 ± 32b 733·6 ± 33c, B
MUFA# 2074 ± 225A 1567 ± 256 2544 ± 214A 1006 ± 225B 1473 ± 214 1547 ± 226B
C16:1cis-9 218·4 ± 26 247·8 ± 29 143·5 ± 24 110·1 ± 26a 244·6 ± 24b 89·9 ± 25a
C18:1cis- 9 1636 ± 184a, b, A 1178 ± 209a 2225 ± 175b, A 793 ± 185B 1044 ± 175 1355 ± 185B
n-6 FAd 2706 ± 438a 754·6 ± 497b 6135 ± 416c 2283 ± 438a 759·7 ± 416b 5876 ± 438a
C18:2n-6 1941 ± 269a 474·8 ± 47b 5003 ± 575c 1686 ± 349a 478 ± 39b 4605 ± 587c
C20:4n-6 557·7 ± 38a 226·8 ± 43b 727·2 ± 37cA 479·3 ± 39a 236·9 ± 37b 902·9 ± 39cB
n-3 FAe 505·0 ± 144a 2385 ± 163b 237·9 ± 136a 556·6 ± 144a 2197 ± 136b 110·1 ± 144a
C18:3n- 3 70·4 ± 11a 93·3 ± 13a 13·3 ± 11b 63·2 ± 11a 85·1 ± 11a 8·4 ± 2b
C20:5n- 3 15·6 ± 3a 476·6 ± 64b 10·0 ± 4a 13·2 ± 3a 400·9 ± 53b 3·7 ± 4a
C22:5n- 3 22·2 ± 4a 133·8 ± 20b 11·3 ± 5a 33·0 ± 4a 114·0 ± 17b 20·1 ± 6a
C22:6n- 3 387·6 ± 19a 1634 ± 180b 191·3 ± 32a 439·3 ± 19a 1556 ± 150b 73·4 ± 34a
PUFA 3219 ± 476a 3144 ± 539a 6404 ± 451b 2844 ± 476a 2962 ± 451a 5999 ± 476b
Δ9 Desaturase indexf 58·8 ± 2a, A 34·4 ± 3b 44·5 ± 2c 27·0 ± 2a, B 34·2 ± 2a, b 39·3 ± 2b
n-6/n-3 ratio 5·3 ± 0·3a 0·3 ± 0·02b 37·6 ± 6c, A 4·0 ± 0·3a 0·4 ± 0·02b 52·3 ± 6c, B
  1. DU6-mouse line selected for high body weight; DUhTP-mouse line selected for high treadmill performance n-3 and n-6 HFD -high fat diet enriched with either n-3 or n-6 polyunsaturated fatty acids
  2. LSM-Least square means, SE-standard error, fatty acid concentrations in mg/100 g fresh tissue;
  3. MUFA-monounsaturated fatty acids; SFA-saturated fatty acids; PUFA-polyunsaturated fatty acids; FA-fatty acids;
  4. a, b, c-significant effect of diet at p ≤ 0.05 within the selected line
  5. A, B-significant effect of selection line at p ≤ 0.05 within the feeding group
  6. + Sum of saturated fatty acids (C10:0+C11:0+C12:0+C13:0+C14:0+C15:0+C16:0+C17:0+C18:0+C20:0+C21:0+C22:0+C23:0+ C24:0)
  7. # Sum of MUFA (C14:1+C16:1+C17:1+∑ C18:1 trans isomers+C18:1cis- 9+C18:1cis- 11+C22:1+C24:1)
  8. d Sum of n-6 fatty acids (C18:3n-6+ C22:4n-6+ C20:3n-6+ C18:2n-6+ C20:4n-6)
  9. e Sum of n-3 fatty acids (C20:3n-3+ C22:6n-3+ C22:5n-3+ C20:5n-3+ C18:4n-3+ C18:3n-3)
  10. f Δ9 Desaturase index = ((C14:1+C16:1+C18:1+C17:1)/(C14:1+C16:1+C18:1+C17:1+C14:0+C16:0+C17:0+ C18:0))*100.